Pogorelova T N, Linde V A, Gunko V O, Selyutina S N
Rostov Scientific-Research Institute of Obstetrics and Pediatrics, Rostov-on-Don, Russia.
Biomed Khim. 2016 Jan-Feb;62(1):69-72. doi: 10.18097/PBMC20166201069.
The levels of zinc, copper, iron, and magnesium ions, and some of their binding proteins have been investigated in an amniotic fluid under the fetal growth retardation (FGR). FGR, developed under conditions of placental insufficiency, is characterized by a decrease in the content of zinc, iron, and magnesium ions and by an increase in the copper content in the amniotic fluid in the II and III trimesters of pregnancy. During these trimesters the levels of ceruloplasmin, ferritin, and Ca2+,Mg2+-ATPase were lower in FGR, while the level of zinc-a-2-glycoprotein was higher than during the same periods of normal pregnancy. Changes in the parameters studied in the amniotic fluid were associated with developmental disorders of the newborns. These changes obviously have a pathogenetic importance in the development of FGR, and the levels of metal ions and their ratio in the amniotic fluid can be used as markers of the pre- and postnatal pathology.
在胎儿生长受限（FGR）情况下，对羊水内锌、铜、铁、镁离子及其某些结合蛋白的水平进行了研究。FGR在胎盘功能不全的情况下发生，其特征为妊娠中期和晚期羊水中锌、铁、镁离子含量降低，铜含量升高。在这些孕期，FGR患者的铜蓝蛋白、铁蛋白和Ca2+，Mg2+-ATP酶水平较低，而锌-α-2-糖蛋白水平高于正常妊娠同期。羊水中所研究参数的变化与新生儿发育障碍有关。这些变化在FGR的发生中显然具有发病机制上的重要性，并且羊水中金属离子的水平及其比例可作为产前和产后病理的标志物。
