Savilov P N
Tambov Regional Hospital, Tambov region, S. Pokrovo-Prigorodnoe, Russia; Burdenko Voronezh State Medical Academy, Voronezh, Russia.
Biomed Khim. 2016 Jan-Feb;62(1):79-81. doi: 10.18097/PBMC20166201079.
The effect of resection of the left lobe of the liver (LR, 15-20% og the organ weight) on hepatic urea formation was investigated in 84 albino rats. The objects of study were the surgery left (LLP), inoperable middle (MLP) lobe of the liver, blood (aorta, v. hepatica, v. porta) and choledochal bile. They studied the urea content. Arginase activity was examined in liver homogenate. On the day 3 and day 7 after resection reduced arginase activity was detected. LR caused a decrease of urea in v. hepatica, but increased urea content in the arterial blood and v. porta. Increase in bile urea on day 7 it was replaced by a decrease observed on day 14 of the postsurgery period. The concentration of urea in the liver on the 3rd day after LR was below the norm, and on the 7th and 14th day was within it. The results indicate a violation of urea operated by hepatocytes of the liver and extrahepatic activation mechanisms of the formation of urea.
在84只白化大鼠中研究了切除肝左叶（LR，占器官重量的15 - 20%）对肝脏尿素生成的影响。研究对象包括手术侧肝左叶（LLP）、不可切除的肝中叶（MLP）、血液（主动脉、肝静脉、门静脉）和胆总管胆汁。检测了尿素含量，并在肝脏匀浆中检测了精氨酸酶活性。切除术后第3天和第7天检测到精氨酸酶活性降低。肝左叶切除导致肝静脉中尿素减少，但动脉血和门静脉中尿素含量增加。术后第7天胆汁尿素增加，而在术后第14天则被观察到的减少所取代。肝左叶切除术后第3天肝脏中尿素浓度低于正常水平，而在第7天和第14天则在正常范围内。结果表明，肝脏肝细胞对尿素的操作以及尿素形成的肝外激活机制受到了破坏。
