干扰素 Lambda 4 基因型与丙型肝炎病毒感染急性期的黄疸和氨基转移酶水平升高相关：InC3 协作研究的结果。
Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.
机构信息
Division of Epidemiology, Biostatistics and Preventive Medicine , University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Department of Epidemiology and Biostatistics , University of California San Francisco.
出版信息
Open Forum Infect Dis. 2016 Feb 8;3(1):ofw024. doi: 10.1093/ofid/ofw024. eCollection 2016 Jan.
Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.
症状性急性 HCV 感染和干扰素 lambda 4（IFNL4）基因型是自发病毒清除的重要预测因子。利用来自多队列数据库（注射队列[InC3]协作）的数据，我们确定了宿主 IFNL4 基因型与急性丙型肝炎病毒感染症状之间的独立关联。这种关联可能解释了一些有症状患者中观察到的更高自发清除率。
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