Sharafi Heidar, Alavian Seyed Moayed, Behnava Bita, Pouryasin Ali, Keshvari Maryam
Iran Hepatitis Network, Tehran, IR Iran ; Middle East Liver Disease (MELD) Center, Tehran, IR Iran ; Armin Pathobiology Laboratory, Tehran, IR Iran.
Iran Hepatitis Network, Tehran, IR Iran ; Middle East Liver Disease (MELD) Center, Tehran, IR Iran.
Hepat Mon. 2014 Oct 1;14(10):e22649. doi: 10.5812/hepatmon.22649. eCollection 2014 Oct.
About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance of HCV infection.
The aim of this study was to evaluate the association between the IFNL4 rs12979860 SNP and spontaneous clearance of HCV infection in Iranian population.
A case-control study was designed on 91 cases with spontaneous HCV infection clearance and 259 patients with persistent HCV infection as the control group. The rs12979860 SNP was assessed as the most common IFNL polymorphism by PCR-RFLP method.
Distribution of rs12979860 CC genotype in the spontaneous clearance group was around two folds of its distribution in chronic hepatitis C group (P < 0.001, OR = 4.09, 95% CI = 2.44-6.86).
The rs12979860 SNP was observed as a strong host genetic factor associated with spontaneous clearance of hepatitis C infection.
约30%的丙型肝炎病毒（HCV）感染者能够自发清除HCV。宿主基因差异会影响HCV感染的结果。干扰素λ（IFNL）基因的单核苷酸多态性（SNP）与HCV感染的自发清除及治疗诱导清除相关。
本研究旨在评估IFNL4 rs12979860 SNP与伊朗人群HCV感染自发清除之间的关联。
设计了一项病例对照研究，91例HCV感染自发清除者为病例组，259例持续性HCV感染者为对照组。采用PCR-RFLP方法评估rs12979860 SNP，其为最常见的IFNL多态性。
rs12979860 CC基因型在自发清除组中的分布约为慢性丙型肝炎组的两倍（P < 0.001，OR = 4.09，95% CI = 2.44 - 6.86）。
rs12979860 SNP被视为与丙型肝炎感染自发清除相关的一个重要宿主遗传因素。
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