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1
A novel reduced intensity conditioning regimen for patients with high-risk hematological malignancies undergoing allogeneic stem cell transplantation.一种用于接受异基因干细胞移植的高危血液系统恶性肿瘤患者的新型低强度预处理方案。
Bone Marrow Transplant. 2016 Jul;51(7):1010-2. doi: 10.1038/bmt.2016.36. Epub 2016 Mar 14.
2
Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.异基因反应性作为血液系统恶性肿瘤治疗的治疗原则。非清髓性预处理的异基因造血细胞移植的临床和免疫学方面的研究。
Dan Med Bull. 2007 May;54(2):112-39.
3
Allogeneic stem cell transplantation for patients with advanced hematological malignancies: comparison of fludarabine-based reduced intensity conditioning versus myeloablative conditioning.异基因干细胞移植治疗晚期血液系统恶性肿瘤患者：基于氟达拉滨的减低剂量预处理与清髓性预处理的比较
J Korean Med Sci. 2007 Apr;22(2):227-34. doi: 10.3346/jkms.2007.22.2.227.
4
Overview of Hematopoietic Cell Transplantation for the Treatment of Hematologic Malignancies.造血细胞移植治疗血液系统恶性肿瘤概述。
Clin Chest Med. 2017 Dec;38(4):575-593. doi: 10.1016/j.ccm.2017.07.001.
5
Stem-cell dose for allogeneic hematopoietic stem cell transplantation in hematological malignancies: is more better?血液系统恶性肿瘤异基因造血干细胞移植的干细胞剂量：越多越好吗？
Leuk Lymphoma. 2009 Sep;50(9):1395-6. doi: 10.1080/10428190903174367.
6
Lowered-intensity preparative regimen for allogeneic stem cell transplantation delays acute graft-versus-host disease but does not improve outcome for advanced hematologic malignancy.异基因干细胞移植的低强度预处理方案可延迟急性移植物抗宿主病，但不能改善晚期血液系统恶性肿瘤的预后。
Biol Blood Marrow Transplant. 2003 Mar;9(3):189-97. doi: 10.1053/bbmt.2003.50012.
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[Allogeneic hematopoietic stem cell transplantation in elderly].[老年患者的异基因造血干细胞移植]
Bull Cancer. 2011 Aug;98(8):915-25. doi: 10.1684/bdc.2011.1407.
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[Therapeutic effect of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimens on hematological malignancies].减低预处理强度的异基因造血干细胞移植治疗血液系统恶性肿瘤的疗效
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):614-7.
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A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease.一种新型的降低强度预处理方案用于异基因造血干细胞移植，与移植物抗宿主病发生率降低相关。
Bone Marrow Transplant. 2004 May;33(9):881-9. doi: 10.1038/sj.bmt.1704454.
10
Comparable kinetics of myeloablation between fludarabine/full-dose busulfan and fludarabine/melphalan conditioning regimens in allogeneic peripheral blood stem cell transplantation.在异基因外周血干细胞移植中，氟达拉滨/全剂量白消安与氟达拉滨/美法仑预处理方案之间的骨髓清除动力学相当。
Bone Marrow Transplant. 2006 Oct;38(7):477-82. doi: 10.1038/sj.bmt.1705480.

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Reduced-Intensity Compared to Nonmyeloablative Conditioning in Patients with Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.在接受异基因造血干细胞移植的非霍奇金淋巴瘤患者中，与非清髓性预处理相比，强度降低的预处理。
Transplant Cell Ther. 2024 Jan;30(1):81-92. doi: 10.1016/j.jtct.2023.09.022. Epub 2023 Oct 1.
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Emergence of human CMV-induced NKG2C+ NK cells is associated with CD8+ T-cell recovery after allogeneic HCT.人巨细胞病毒诱导的 NKG2C+NK 细胞的出现与异基因造血干细胞移植后 CD8+T 细胞的恢复有关。
Blood Adv. 2023 Oct 10;7(19):5784-5798. doi: 10.1182/bloodadvances.2022008952.
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EASIX score predicts inferior survival after allogeneic hematopoietic cell transplantation.EASIX 评分预测异基因造血细胞移植后生存不良。
Bone Marrow Transplant. 2023 May;58(5):498-505. doi: 10.1038/s41409-023-01922-8. Epub 2023 Jan 31.
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Outcomes of Refractory Cytomegalovirus Infection in the First Year after Allogeneic Hematopoietic Cell Transplantation.异基因造血细胞移植后第一年难治性巨细胞病毒感染的结果。
Transplant Cell Ther. 2022 Jul;28(7):403.e1-403.e7. doi: 10.1016/j.jtct.2022.04.016. Epub 2022 Apr 25.
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Efficacy and safety of isavuconazole compared with voriconazole as primary antifungal prophylaxis in allogeneic hematopoietic cell transplant recipients.伊曲康唑与伏立康唑作为异基因造血细胞移植受者一线抗真菌预防治疗的疗效和安全性比较。
Med Mycol. 2021 Oct 4;59(10):970-979. doi: 10.1093/mmy/myab025.
6
Impact of Preemptive Therapy for Cytomegalovirus on Hospitalizations and Cost after Hematopoietic Stem Cell Transplantation.巨细胞病毒抢先治疗对造血干细胞移植后住院情况及费用的影响
Biol Blood Marrow Transplant. 2020 Oct;26(10):1937-1947. doi: 10.1016/j.bbmt.2020.06.025. Epub 2020 Jul 5.
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Impact of Preemptive Therapy for Cytomegalovirus on Toxicities after Allogeneic Hematopoietic Cell Transplantation in Clinical Practice: A Retrospective Single-Center Cohort Study.临床实践中巨细胞病毒抢先治疗对异基因造血细胞移植后毒性的影响：一项回顾性单中心队列研究
Biol Blood Marrow Transplant. 2020 Aug;26(8):1482-1491. doi: 10.1016/j.bbmt.2020.03.019. Epub 2020 Apr 19.
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A Single-Center, Open-Label Trial of Isavuconazole Prophylaxis against Invasive Fungal Infection in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation.一项关于异氟康唑预防异基因造血细胞移植患者侵袭性真菌感染的单中心开放标签试验。
Biol Blood Marrow Transplant. 2020 Jun;26(6):1195-1202. doi: 10.1016/j.bbmt.2020.02.009. Epub 2020 Feb 20.
9
Cytomegalovirus Infection in Allogeneic Hematopoietic Cell Transplantation Managed by the Preemptive Approach: Estimating the Impact on Healthcare Resource Utilization and Outcomes.CMV 感染的异基因造血细胞移植的抢先治疗：估计对医疗资源利用和结局的影响。
Biol Blood Marrow Transplant. 2019 Apr;25(4):791-799. doi: 10.1016/j.bbmt.2018.11.012. Epub 2018 Nov 24.

本文引用的文献

1
High Disease-Free Survival with Enhanced Protection against Relapse after Double-Unit Cord Blood Transplantation When Compared with T Cell-Depleted Unrelated Donor Transplantation in Patients with Acute Leukemia and Chronic Myelogenous Leukemia.与急性白血病和慢性粒细胞白血病患者的T细胞去除无关供体移植相比，双单位脐血移植后具有更高的无病生存率，并能增强对复发的保护作用。
Biol Blood Marrow Transplant. 2015 Nov;21(11):1985-93. doi: 10.1016/j.bbmt.2015.07.029. Epub 2015 Jul 31.
2
Fludarabine Melphalan reduced-intensity conditioning allotransplanation provides similar disease control in lymphoid and myeloid malignancies: analysis of 344 patients.氟达拉滨美法仑减低剂量预处理异基因移植在淋巴系和髓系恶性肿瘤中提供相似的疾病控制：344例患者分析
Bone Marrow Transplant. 2014 Jan;49(1):17-23. doi: 10.1038/bmt.2013.142. Epub 2013 Sep 23.
3
A novel reduced-intensity conditioning regimen induces a high incidence of sustained donor-derived neutrophil and platelet engraftment after double-unit cord blood transplantation.一种新型的低强度预处理方案可在双份脐血移植后诱导供者来源的中性粒细胞和血小板持续植入。
Biol Blood Marrow Transplant. 2013 May;19(5):799-803. doi: 10.1016/j.bbmt.2013.02.007. Epub 2013 Feb 14.
4
Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity?弥漫性大 B 细胞淋巴瘤同种异体移植的预处理方案：清髓性或强度降低的？
Blood. 2012 Nov 15;120(20):4256-62. doi: 10.1182/blood-2012-06-436725. Epub 2012 Sep 24.
5
Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 trial.在首次完全缓解的急性髓系白血病患者中，异基因造血细胞移植前采用低强度预处理与标准预处理的比较：一项前瞻性、开放标签、随机 3 期临床试验。
Lancet Oncol. 2012 Oct;13(10):1035-44. doi: 10.1016/S1470-2045(12)70349-2. Epub 2012 Sep 7.
6
Randomized study of 2 reduced-intensity conditioning strategies for human leukocyte antigen-matched, related allogeneic peripheral blood stem cell transplantation: prospective clinical and socioeconomic evaluation.随机研究 2 种降低强度的造血干细胞移植预处理方案在人类白细胞抗原匹配的相关异基因外周血干细胞移植中的应用：前瞻性临床和社会经济学评估。
Cancer. 2013 Feb 1;119(3):602-11. doi: 10.1002/cncr.27786. Epub 2012 Aug 14.
7
A disease risk index for patients undergoing allogeneic stem cell transplantation.异体干细胞移植患者的疾病风险指数。
Blood. 2012 Jul 26;120(4):905-13. doi: 10.1182/blood-2012-03-418202. Epub 2012 Jun 18.
8
Outcome of lower-intensity allogeneic transplantation in non-Hodgkin lymphoma after autologous transplantation failure.自体移植失败后低强度异基因移植治疗非霍奇金淋巴瘤的结局。
Biol Blood Marrow Transplant. 2012 Aug;18(8):1255-64. doi: 10.1016/j.bbmt.2011.12.581. Epub 2011 Dec 23.
9
Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia.氟达拉滨、噻替哌、环磷酰胺和 ATG 组成的中等强度预处理方案用于治疗复发或高危急性髓系白血病老年患者的异基因造血干细胞移植。
Ann Hematol. 2012 Jan;91(1):47-55. doi: 10.1007/s00277-011-1253-9. Epub 2011 May 17.
10
Defining the intensity of conditioning regimens: working definitions.定义预处理强度：工作定义。
Biol Blood Marrow Transplant. 2009 Dec;15(12):1628-33. doi: 10.1016/j.bbmt.2009.07.004. Epub 2009 Sep 1.

A novel reduced intensity conditioning regimen for patients with high-risk hematological malignancies undergoing allogeneic stem cell transplantation.

作者信息

Hobbs G S, Kaur N, Hilden P, Ponce D, Cho C, Castro-Malaspina H R, Giralt S, Goldberg J D, Jakubowski A A, Papadopoulos E B, Sauter C, Koehne G, Yahalom J, Delvin S, Barker J N, Perales M-A

机构信息

Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, Department of Medicine, New York, NY, USA.

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

出版信息

Bone Marrow Transplant. 2016 Jul;51(7):1010-2. doi: 10.1038/bmt.2016.36. Epub 2016 Mar 14.

DOI:10.1038/bmt.2016.36
PMID:26974271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5330665/
Abstract
摘要