在体外和体内使用人重组粒细胞巨噬细胞集落刺激因子（GMCSF）使人类急性髓系白血病（AML）细胞永生化失败。
Failure to immortalise human AML cells using human recombinant GMCSF in vitro and in vivo.
作者信息
Clutterbuck R, Newman A, Powles R, Kwong Y, Millar J, Shepherd V, Smith C
机构信息
Leukaemia Unit, Royal Marsden Hospital, Sutton, U.K.
出版信息
Bone Marrow Transplant. 1989 Dec;4 Suppl 4:40-1.
PMID:2697435
Abstract
We have failed to find any evidence that human recombinant GM-CSF can immortalize human AML cells grown in liquid culture or as nodules in immune deprived mice. In previous clinical studies and a controlled trial currently underway there is no evidence of irreversible acceleration of the disease.
摘要
我们未能找到任何证据表明重组人粒细胞巨噬细胞集落刺激因子（GM-CSF）能使在液体培养中生长的人急性髓系白血病（AML）细胞永生化，或在免疫缺陷小鼠体内形成结节。在之前的临床研究以及目前正在进行的一项对照试验中，均没有证据表明该疾病会出现不可逆的加速进展。
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