Ng L L, Coppack S W
Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, UK.
Diabetes Res. 1989 Jul;11(3):103-7.
We describe a computer program based on the minimal model of Bergman et al., which has been used to control euglycaemic hyperinsulinaemic clamps and to derive the insulin sensitivity index (Si) from clamp data. Clamps were undertaken on 33 subjects with a range of insulin resistance. The steady state glucose had an acceptable coefficient of variation (c.v.) and was close to the desired clamp level. The c.v. of the steady state glucose infusion rate was smaller than for other clamp programmes. The Si was correlated with metabolic clearance rate for glucose (MCR) divided by the change in insulin concentration. Our results suggest that the assumptions of the minimal model hold true in the euglycaemic hyper-insulinaemic situation and demonstrate that a minimal-model-derived program can achieve acceptable clamping.
我们描述了一种基于伯格曼等人的最小模型的计算机程序，该程序已用于控制正常血糖高胰岛素钳夹试验，并从钳夹数据中推导胰岛素敏感性指数（Si）。对33名具有不同胰岛素抵抗程度的受试者进行了钳夹试验。稳态血糖具有可接受的变异系数（c.v.），并且接近所需的钳夹水平。稳态葡萄糖输注率的c.v. 比其他钳夹程序更小。Si与葡萄糖代谢清除率（MCR）除以胰岛素浓度变化相关。我们的结果表明，最小模型的假设在正常血糖高胰岛素情况下成立，并证明基于最小模型推导的程序可以实现可接受的钳夹。
