Rivero-Juarez A, Gonzalez R, Frias M, Manzanares-Martín B, Rodriguez-Cano D, Perez-Camacho I, Gordon A, Cuenca F, Camacho A, Pineda J A, Peña J, Rivero A
Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain.
Immunology Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Universidad de Córdoba, Córdoba, Spain.
Pharmacogenomics J. 2017 Jul;17(4):360-365. doi: 10.1038/tpj.2016.19. Epub 2016 Mar 15.
Our aim was to evaluate the killer cell immunoglobulin-like receptors (KIRs) as a marker for the development of thrombocytopenia secondary to Peg-interferon (IFN) therapy in a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infected patients. Patients were naive to HCV treatment, receiving a first course of Peg-IFN/Ribavirin combination therapy. Total platelet count (cells ml) was determined at each visit, determining platelet decline from baseline to weeks 1, 2, 4, 8 and 12 after starting therapy. The end point of the study was development of thrombocytopenia, defined as a platelet count of <1 50 000 cells ml. Fifty-eight HIV/HCV co-infected patients were included in the study, of whom 20 (34.4%) developed thrombocytopenia. The absence of KIR2DS2 was associated with higher and faster rate of thrombocytopenia (54.2% vs 22.5%; P=0.012; 6.6 vs 10.3 weeks; P=0.008). The absence of KIR2DS2 was associated with a greater decline in platelet count and development of thrombocytopenia during Peg-IFN treatment in HIV/HCV co-infected patients.
我们的目的是在一组人类免疫缺陷病毒（HIV）/丙型肝炎病毒（HCV）合并感染患者中，评估杀伤细胞免疫球蛋白样受体（KIRs）作为聚乙二醇干扰素（IFN）治疗继发血小板减少症发生的标志物。患者既往未接受过HCV治疗，正在接受聚乙二醇干扰素/利巴韦林联合治疗的首个疗程。每次就诊时测定总血小板计数（细胞数/毫升），确定从基线到开始治疗后第1、2、4、8和12周的血小板下降情况。研究的终点是血小板减少症的发生，定义为血小板计数<150000细胞/毫升。58例HIV/HCV合并感染患者纳入研究，其中20例（34.4%）发生血小板减少症。KIR2DS2缺失与血小板减少症的发生率更高、速度更快相关（54.2%对22.5%；P=0.012；6.6周对10.3周；P=0.008）。在HIV/HCV合并感染患者中，KIR2DS2缺失与聚乙二醇干扰素治疗期间血小板计数下降幅度更大及血小板减少症的发生相关。
