Highly selective Markovnikov hydroboration of alkyl-substituted terminal alkenes with a phosphine-copper(i) catalyst.
作者信息
Iwamoto Hiroaki, Kubota Koji, Ito Hajime
机构信息
Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan.
出版信息
Chem Commun (Camb). 2016 May 1;52(35):5916-9. doi: 10.1039/c6cc00782a. Epub 2016 Mar 15.
PMID:26975671
Abstract
A new method has been developed for the Markovnikov hydroboration of alkyl-substituted terminal alkenes. Notably, the use of a bulky bisphosphine-copper(i) catalyst system resulted in high regioselectivity to afford secondary alkylboronates from the corresponding terminal alkenes (branch/linear = 92 : 8-97 : 3). This method also exhibited good functional group compatibility.
摘要
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