对映选择性铑(III)催化的非活化末端烯烃的 Markovnikov 硼氢化反应。
Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes.
机构信息
School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, United Kingdom.
Pharmaceutical Technology and Development, AstraZeneca , Silk Road Business Park, Charter Way, Macclesfield SK10 2NA, United Kingdom.
出版信息
J Am Chem Soc. 2017 Jul 12;139(27):9148-9151. doi: 10.1021/jacs.7b05149. Epub 2017 Jun 30.
Abstract
We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp-sp hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.
摘要
我们报道了首例非手性 Rh 催化的末端非活化烯烃的 Markovnikov 型硼氢化反应。使用一种新型的 sp-sp 杂化二硼试剂和水作为质子源，广泛的烯烃可进行硼氢化反应，以高区域和对映选择性得到仲硼酸酯。
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