配对血浆滤过吸附可改善感染性休克的血流动力学。
Coupled plasma filtration adsorption improves hemodynamics in septic shock.
作者信息
Franchi Matteo, Giacalone Marilù, Traupe Ippolito, Rago Rocco, Baldi Giacomo, Giunta Francesco, Forfori Francesco
机构信息
University of Pisa, 56126 Pisa, Italy.
Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy.
出版信息
J Crit Care. 2016 Jun;33:100-5. doi: 10.1016/j.jcrc.2016.02.005. Epub 2016 Feb 15.
PURPOSE
Septic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock.
MATERIALS AND METHODS
We retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment.
RESULTS
Coupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values.
CONCLUSION
Treatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure.
目的
感染性休克涉及对感染的免疫反应失调。这可能导致血流动力学功能障碍和多器官功能衰竭。本研究的主要目的是评估配对血浆滤过吸附（CPFA）对感染性休克患者血流动力学状况的影响。
材料与方法
我们回顾性分析了21例入住重症监护病房且诊断为感染性休克的成年患者的数据，比较了CPFA治疗前和治疗后的资料。他们最多接受5个疗程的治疗。
结果
配对血浆滤过吸附治疗与平均动脉压显著升高（P <.001）、血管活性/正性肌力药物需求减少（P =.007）以及肾功能改善相关。在白细胞增多或白细胞减少的患者中，白细胞计数恢复到参考值范围。
结论
CPFA治疗可改善感染性休克患者的血流动力学参数，减轻器官功能衰竭。
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