脂蛋白脂肪酶四种多态性与阿尔茨海默病风险相关性的荟萃分析。
Meta-analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer's disease.
作者信息
Ren Liang, Ren Xingxing
机构信息
Fourth Military Medical University, No. 169, Changle West Road, Xi'an 710032, Shaanxi Province, China.
Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160, Pujian Road, Shanghai 200127, China.
出版信息
Neurosci Lett. 2016 Apr 21;619:73-8. doi: 10.1016/j.neulet.2016.03.021. Epub 2016 Mar 11.
AIMS
We evaluated the contributions of four polymorphisms of the lipoprotein lipase (LPL) gene to the risk of Alzheimer's disease (AD).
METHODS
Through a comprehensive literature search for genetic variants of LPL involved in AD association studies, we found four polymorphisms for the current meta-analyses. These polymorphisms were Asn291Ser(rs268), PvuII(rs285), HindIII(rs320) and Ser447Ter(rs328).
RESULTS
In total, eight studies with 5064 cases and 5016 controls were retrieved for the meta-analyses of the four genetic variants. The analyses showed that Asn291Ser(rs268) (OR=2.34, 95% CI=1.05-5.25, P=0.04), HindIII(rs320) (OR=1.44, 95% CI=1.17-1.78, P=0.0006), and Ser447Ter(rs328) (OR=0.80, 95% CI=0.66-0.98, P=0.03) were significantly associated with a risk of AD. No association was found between the PvuII(rs285) polymorphism and the risk of AD.
CONCLUSIONS
Our results showed that Asn291Ser(rs268), HindIII(rs320) and Ser447Ter(rs328) polymorphisms of LPL were associated with a risk of AD. Asn291Ser(rs268) and HindIII(rs320) were predisposing factors of AD, whereas Ser447Ter(rs328) showed a protective effect for AD.
目的
我们评估了脂蛋白脂肪酶（LPL）基因的四种多态性对阿尔茨海默病（AD）风险的影响。
方法
通过全面检索参与AD关联研究的LPL基因变异的文献，我们为当前的荟萃分析找到了四种多态性。这些多态性分别是Asn291Ser（rs268）、PvuII（rs285）、HindIII（rs320）和Ser447Ter（rs328）。
结果
总共检索到八项研究，其中包括5064例病例和5016例对照，用于这四种基因变异的荟萃分析。分析表明，Asn291Ser（rs268）（比值比[OR]=2.34，95%置信区间[CI]=1.05 - 5.25，P=0.04）、HindIII（rs320）（OR=1.44，95% CI=1.17 - 1.78，P=0.0006）和Ser447Ter（rs328）（OR=0.80，95% CI=0.66 - 0.98，P=0.03）与AD风险显著相关。未发现PvuII（rs285）多态性与AD风险之间存在关联。
结论
我们的结果表明，LPL基因的Asn291Ser（rs268）、HindIII（rs320）和Ser447Ter（rs328）多态性与AD风险相关。Asn291Ser（rs268）和HindIII（rs320）是AD的易感因素，而Ser447Ter（rs328）对AD具有保护作用。
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