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3
Sex differences in behavioral outcome following neonatal hypoxia ischemia: insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury.新生儿缺氧缺血后行为结局的性别差异：来自临床荟萃分析和诱导缺氧缺血性脑损伤啮齿动物模型的研究。
Exp Neurol. 2014 Apr;254:54-67. doi: 10.1016/j.expneurol.2014.01.003. Epub 2014 Jan 13.
4
Neuro-protective effects of growth hormone (GH) after hypoxia-ischemia injury in embryonic chicken cerebellum.生长激素（GH）对胚胎鸡小脑缺氧缺血损伤的神经保护作用。
Gen Comp Endocrinol. 2013 Mar 1;183:17-31. doi: 10.1016/j.ygcen.2012.12.004. Epub 2012 Dec 19.
5
MicroRNAs in the pineal gland: miR-483 regulates melatonin synthesis by targeting arylalkylamine N-acetyltransferase.松果体中的 microRNAs：miR-483 通过靶向芳香族胺 N-乙酰基转移酶调节褪黑素的合成。
J Biol Chem. 2012 Jul 20;287(30):25312-24. doi: 10.1074/jbc.M112.356733.
6
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BMC Syst Biol. 2011 Sep 9;5:141. doi: 10.1186/1752-0509-5-141.
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Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury.阻断 1 型胰岛素样生长因子受体表达会加重缺氧/缺血损伤后的神经元凋亡。
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Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy.低温治疗脑病新生儿睡眠-觉醒周期延迟发作，结局良好。
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Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.在患有晚期失眠的重度抑郁症患者中，miR-182 的遗传变异和异常前体处理与昼夜节律调节剂有关。
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MicroRNA-122 modulates the rhythmic expression profile of the circadian deadenylase Nocturnin in mouse liver.MicroRNA-122 调控小鼠肝脏中昼夜节律脱腺苷酶 Nocturnin 的节律表达谱。
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[缺氧缺血性脑损伤新生大鼠松果体中miRNA - 182和Clock mRNA的表达谱]

[Expression profiles of miRNA-182 and Clock mRNA in the pineal gland of neonatal rats with hypoxic-ischemic brain damage].

作者信息

Han Xing, Ding Xin, Xu Li-Xiao, Liu Ming-Hua, Feng Xing

机构信息

Department of Neonatology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar;18(3):270-6. doi: 10.7499/j.issn.1008-8830.2016.03.016.

DOI:10.7499/j.issn.1008-8830.2016.03.016
PMID:26975828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7389990/
Abstract

OBJECTIVE

To study the changes of miRNA expression in the pineal gland of neonatal rats with hypoxic-ischemic brain damage (HIBD) and the possible roles of miRNA in the pathogenesis of circadian rhythm disturbance after HIBD.

METHODS

Seven-day-old Sprague-Dawley (SD) rats were randomly divided into 2 groups: HIBD and sham-operated. HIBD was induced according to the Rice-Vannucci method. The pineal glands were obtained 24 hours after the HIBD event. The expression profiles of miRNAs were determined using GeneChip technigue and quantitative real-time PCR (RT-PCR). Then the miRNA which was highly expressed was selected. The expression levels of the chosen miRNA were detected in different tissues (lungs, intestines, stomach, kidneys, cerebral cortex, pineal gland). RT-PCR analysis was performed to measure the expression profiles of the chosen miRNA and the targeted gene Clock mRNA in the pineal gland at 0, 24, 48 and 72 hours after HIBD.

RESULTS

miRNA-182 that met the criteria was selected by GeneChip and RT-PCR. miRNA-182 was highly expressed in the pineal gland. Compared with the sham-operated group, the expression of miRNA-182 was significantly up-regulated in the pineal gland at 24 and 48 hours after HIBD (P<0.05). Compared with the sham-operated group, Clock mRNA expression in the HIBD group increased at 0 hour after HIBD, decreased at 48 hours after HIBD and increased at 72 hours after HIBD (P<0.05).

CONCLUSIONS

miRNA-182 may be involved in the pathogenesis of circadian rhythm disturbance after HIBD.

摘要

目的

研究缺氧缺血性脑损伤（HIBD）新生大鼠松果体中微小RNA（miRNA）表达的变化，以及miRNA在HIBD后昼夜节律紊乱发病机制中的可能作用。

方法

将7日龄的Sprague-Dawley（SD）大鼠随机分为2组：HIBD组和假手术组。按照Rice-Vannucci法诱导HIBD。HIBD造模后24小时获取松果体。采用基因芯片技术和定量实时聚合酶链反应（RT-PCR）测定miRNA的表达谱。然后筛选出高表达的miRNA。检测所选miRNA在不同组织（肺、肠、胃、肾、大脑皮质、松果体）中的表达水平。进行RT-PCR分析，以检测HIBD后0、24、48和72小时松果体中所选miRNA和靶向基因Clock mRNA的表达谱。

结果

通过基因芯片和RT-PCR筛选出符合标准的miRNA-182。miRNA-182在松果体中高表达。与假手术组相比，HIBD后24和48小时松果体中miRNA-182的表达显著上调（P<0.05）。与假手术组相比，HIBD组Clock mRNA表达在HIBD后0小时升高，48小时降低，72小时升高（P<0.05）。

结论

miRNA-182可能参与HIBD后昼夜节律紊乱的发病机制。