胰岛素样生长因子-I在原发性卵巢癌中的作用——欧洲卵巢癌协作组（OVCAD）的一项研究

Role of IGF-I in Primary Ovarian Cancer - A Study of the OVCAD European Consortium.

作者信息

Rohr Irena, Zeillinger Robert, Heinrich Michaela, Concin Nicole, Vergote Ignace, Nassir Mani, Mahner Sven, VAN Nieuwenhuysen Els, Trillsch Fabian, Cacsire-Tong Dan, Chekerov Radoslav, Sehouli Jalid, Braicu Elena I

机构信息

Gynecological Tumor Center and European Competence Center for Ovarian Cancer, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria Ludwig Boltzmann Cluster Translational Oncology, General Hospital of Vienna, Vienna, Austria.

出版信息

Anticancer Res. 2016 Mar;36(3):1015-22.

PMID:26976992

Abstract

BACKGROUND/AIM: IGF-I (insulin growth factor 1) is crucially involved in cellular proliferation. Moreover, deregulation of IGF-I has been shown to be relevant in the carcinogenesis of various tumor entities. However, the impact of IGF-I in epithelial ovarian cancer (EOC) is unclear. In the present study, we investigated the predictive and prognostic role of circulatory IGF-I in primary EOC patients.

PATIENTS AND METHODS

In the FP6 European Project "OVCAD", 275 consecutive primary EOC patients were enrolled. Patients were eligible if radical cytoreductive surgery and platinum-based chemotherapy were performed. Plasma IGF-I was detected using ELISA.

RESULTS

Increased plasma IGF-I levels were more frequently found in well-differentiated epithelial ovarian carcinoma (p=0.0047). A weak correlation was observed between IGF-I levels and CA-125 in patients with serous EOC (p=0.04). No association between IGF-I expression and other clinico-pathological parameters was observed.

CONCLUSION

IGF-I is overexpressed in patients with well-differentiated EOC. Further studies are warranted to elucidate the role of IGF-I in this sub-group of patients.

摘要

背景/目的：胰岛素样生长因子1（IGF-I）在细胞增殖中起关键作用。此外，IGF-I失调已被证明与多种肿瘤实体的致癌作用相关。然而，IGF-I在上皮性卵巢癌（EOC）中的作用尚不清楚。在本研究中，我们调查了循环IGF-I在原发性EOC患者中的预测和预后作用。