Amerio Andrea, Tonna Matteo, Odone Anna, Stubbs Brendon, Ghaemi S Nassir
Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy; Mood Disorders Program, Tufts Medical Center, Boston, MA, USA.
Department of Mental Health, Local Health Service, Parma, Italy.
Shanghai Arch Psychiatry. 2015 Oct;27(5):307-10. doi: 10.11919/j.issn.1002-0829.215123.
Partly due to the overlap of symptom groupings in DSM, psychiatric comorbidity is extremely common. One of the most common and difficult to manage comorbid conditions is the co-occurrence of bipolar disorder (BD) and obsessive compulsive disorder (OCD). However, the key nosological question about this condition - whether they are two distinct disorders or a subtype of one of the disorders - remains unresolved. In order to help address this unanswered question, we updated our recent systematic review, searching the electronic databases MEDLINE, Embase, and PsycINFO to specifically investigate the heredity in BD-OCD patients. We identified a total of 8 relevant papers, the majority of which found that, compared to non-BD-OCD patients, BD-OCD patients were more likely to have a family history for mood disorders and less likely to have a family history for OCD. These results support the view that the majority of cases of comorbid BD-OCD are, in fact, BD cases. If confirmed in larger, more focused studies, this conclusion would have important nosological and clinical implications.
部分由于《精神疾病诊断与统计手册》（DSM）中症状分组的重叠，精神疾病共病极为常见。最常见且最难处理的共病情况之一是双相情感障碍（BD）和强迫症（OCD）同时出现。然而，关于这种情况的关键分类学问题——它们是两种不同的疾病还是其中一种疾病的亚型——仍未得到解决。为了帮助回答这个未解决的问题，我们更新了近期的系统综述，检索了电子数据库MEDLINE、Embase和PsycINFO，以专门研究BD - OCD患者的遗传情况。我们共识别出8篇相关论文，其中大多数发现，与非BD - OCD患者相比，BD - OCD患者更有可能有情绪障碍家族史，而有OCD家族史的可能性较小。这些结果支持这样一种观点，即共病的BD - OCD的大多数病例实际上是BD病例。如果在更大规模、更具针对性的研究中得到证实，这一结论将具有重要的分类学和临床意义。
