Alikhanov R B, Sorokina A V, Zabozlaev F G, Panchenkov D N, Astakhov D A
Moscow Clinical Scientific Center; Department of Surgery, M.V. Lomonosov Moscow State University.
Department of Surgery, M.V. Lomonosov Moscow State University.
Khirurgiia (Mosk). 2016(2):66-68. doi: 10.17116/hirurgia2016266-68.
Comparative morphologic assessment of the liver tissue response to the preoperative infusion of octreotide and prednisolon after the major hepatic resection was studied in rats.
25 male Wistar rats weighing 230--280 g were used. All rats underwent 70--80% hepatectomy. The rats were divided into three groups according to the infusions before hepatectomy: group 1 (n=7) -- received octreotide, group 2 (n=8) -- prednisolone, group 3 (n=10) -- 0.9% saline solution as the control. Histologic features of the remnant liver were evaluated in the sacrificied rats after 72 hours post-hepatectomy.
In the group 1 we observed more rapid decrease of edema and tendency to the accelerated regeneration process of hepatocytes.
Octreotide infusion before the major hepatic resection may have protective effect on hepatocytes and accelerate the regeneration in the remnant liver.
在大鼠中研究肝大部切除术后肝组织对术前注射奥曲肽和泼尼松龙的反应的比较形态学评估。
使用25只体重230 - 280克的雄性Wistar大鼠。所有大鼠均接受70 - 80%肝切除术。根据肝切除术前的注射情况将大鼠分为三组：第1组（n = 7）——接受奥曲肽，第2组（n = 8）——泼尼松龙，第3组（n = 10）——0.9%生理盐水作为对照。在肝切除术后72小时处死大鼠，评估残余肝脏的组织学特征。
在第1组中，我们观察到水肿更快消退以及肝细胞加速再生的趋势。
肝大部切除术前注射奥曲肽可能对肝细胞有保护作用，并加速残余肝脏的再生。
