钯催化的二氢呋喃间的对映选择性碳醚化反应。
Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans.
机构信息
Department of Organic Chemistry, University of Geneva , 30 quai Ernest Ansermet, 1211 Geneva, Switzerland.
出版信息
J Am Chem Soc. 2016 Mar 30;138(12):4014-7. doi: 10.1021/jacs.6b02158. Epub 2016 Mar 18.
PMID:26978243
Abstract
A novel enantioselective Pd-catalyzed intermolecular carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.
摘要
报道了一种新型的对映选择性 Pd 催化的二氢呋喃分子间碳醚化反应。手性双膦单氧化物配体的原位生成是至关重要的，并且已经基于此方法确定了通用的催化体系。它为各种稠合的四氢呋喃并苯并呋喃提供了一致高产率和对映体过量的方法。
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