AKT 抑制剂在癌症治疗中有未来吗？
Is There a Future for AKT Inhibitors in the Treatment of Cancer?
机构信息
Breast Cancer Program, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University, Nashville, Tennessee.
出版信息
Clin Cancer Res. 2016 Jun 1;22(11):2599-601. doi: 10.1158/1078-0432.CCR-16-0100. Epub 2016 Mar 15.
Abstract
An AKT inhibitor plus an antiestrogen exhibited no significant clinical activity in patients with ER(+)/HER2(-) breast cancer despite laboratory studies supporting an antitumor effect for both drugs combined. These results raise concerns about the development of AKT inhibitors in unselected patients whose tumors have unknown dependence on the PI3K/AKT pathway. Clin Cancer Res; 22(11); 2599-601. ©2016 AACRSee related article by Ma et al., p. 2650.
摘要
尽管实验室研究表明 AKT 抑制剂与抗雌激素药物联合应用具有抗肿瘤作用，但在 ER(+)/HER2(-) 乳腺癌患者中，联合用药并未显示出显著的临床活性。这些结果令人担忧的是，在那些肿瘤对 PI3K/AKT 通路的依赖性尚不清楚的未选择患者中开发 AKT 抑制剂的情况。临床癌症研究; 22(11); 2599-601. ©2016AACRSee 相关文章由 Ma 等人，第 2650 页。
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