Durban Mercè, García Désireé, Obradors Albert, Vernaeve Valerie, Vassena Rita
Clinica EUGIN, Travessera de les Corts 322, 08029, Barcelona, Spain.
Fundació EUGIN, Travessera de les Corts 314, 08029, Barcelona, Spain.
J Assist Reprod Genet. 2016 Aug;33(8):1009-15. doi: 10.1007/s10815-016-0686-4. Epub 2016 Mar 16.
The objective of this prospective, single center study was to develop a personalized training scheme for intracytoplasmic sperm injection (ICSI) through the use of learning curve-cumulative summation (LC-CUSUM), which allows to tailor training to the trainee performance, and to validate it against the performance of experienced embryologists.
Five trainees microinjected latex microspheres (LM) into vitro matured oocytes. A microinjection was considered successful when the oocyte did not lyse in the 24 h following the injection.
Each trainee became proficient at ICSI after a variable number of injections, ranging from 35 to 80. Trainees that achieved proficiency went on to perform ICSI with human gametes in a clinical setting with proficiency comparable to that of experienced embryologists.
We show that LC-CUSUM based personalized ICSI training is feasible and allows trainees to be as proficient as trained embryologists when treating actual patients.
这项前瞻性单中心研究的目的是通过使用学习曲线累积求和法（LC-CUSUM）来制定个性化的卵胞浆内单精子注射（ICSI）培训方案，该方法能够根据受训者的表现调整培训，并与经验丰富的胚胎学家的表现进行验证。
五名受训者将乳胶微球（LM）显微注射到体外成熟的卵母细胞中。当卵母细胞在注射后24小时内未裂解时，显微注射被认为是成功的。
每位受训者在进行了35至80次不等的注射后都熟练掌握了ICSI技术。达到熟练程度的受训者随后在临床环境中对人类配子进行ICSI操作，其熟练程度与经验丰富的胚胎学家相当。
我们表明，基于LC-CUSUM的个性化ICSI培训是可行的，并且在治疗实际患者时，受训者能够与训练有素的胚胎学家一样熟练。
