Solignac I
Tijdschr Psychiatr. 2016;58(3):228-31.
We study the case of a 12-year-old girl who, following intra-uterine exposure to valproate, was diagnosed with foetal valproate syndrome, characterised at birth by dysmorphic features. The use of valproate during pregnancy (because of epilepsy or bipolar disorder) can cause not only structural defects in the growing foetus, but also problems in cognitive development and in adaptive and emotional/behavioural functioning in later life. We evaluate these domains of development in our discussion and suggest several other drugs, less harmful than valproate, which can be used to treat epilepsy or bipolar disorder during pregnancy.
我们研究了一名12岁女孩的病例，该女孩在子宫内接触丙戊酸盐后，被诊断为胎儿丙戊酸盐综合征，出生时具有畸形特征。孕期使用丙戊酸盐（由于癫痫或双相情感障碍）不仅会导致发育中的胎儿出现结构缺陷，还会引发认知发展问题以及日后生活中的适应和情感/行为功能问题。我们在讨论中评估了这些发育领域，并提出了几种比丙戊酸盐危害小的其他药物，可用于治疗孕期的癫痫或双相情感障碍。
