微小RNA-203通过靶向PIBF1/Akt信号通路抑制胃癌生长。
MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling.
作者信息
Chu Shao-Jun, Wang Ge, Zhang Peng-Fei, Zhang Rui, Huang Yan-Xia, Lu Yun-Min, Da Wei, Sun Qun, Zhang Jing, Zhu Jin-Shui
机构信息
Department of Gerontology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Shanghai, 200233, China.
Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Yishan Road No. 600, Shanghai, 200233, China.
出版信息
J Exp Clin Cancer Res. 2016 Mar 15;35:47. doi: 10.1186/s13046-016-0323-1.
BACKGROUND
MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive.
RESULTS
Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression.
CONCLUSIONS
MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.
背景
微小RNA（miRNA）已被证明参与包括肿瘤生长在内的多种致瘤行为。但是，miRNA-203在胃癌（GC）中的临床意义和功能仍不清楚。
结果
miRNA-203表达降低与GC患者的肿瘤大小、预后不良和复发相关。miR-203过表达或其靶标孕激素免疫调节结合因子1（PIBF1）的敲低在体外和体内均抑制GC生长，而miR-203敲低则促进GC增殖。此外，PIBF1过表达减弱了miR-203对GC生长的抑制作用，并增强了对p-Akt表达的影响。
结论
MiR-203作为一种肿瘤生物标志物，通过靶向PIBF1/Akt信号通路抑制GC生长，表明它可能对GC治疗具有重要的治疗潜力。
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