Semo Jonathan, Nicenboim Julian, Yaniv Karina
Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
Development. 2016 Mar 15;143(6):924-35. doi: 10.1242/dev.132431.
The lymphatic system is a blind-ended network of vessels that plays important roles in mediating tissue fluid homeostasis, intestinal lipid absorption and the immune response. A profound understanding of the development of lymphatic vessels, as well as of the molecular cues governing their formation and morphogenesis, might prove essential for our ability to treat lymphatic-related diseases. The embryonic origins of lymphatic vessels have been debated for over a century, with a model claiming a venous origin for the lymphatic endothelium being predominant. However, recent studies have provided new insights into the origins of lymphatic vessels. Here, we review the molecular mechanisms controlling lymphatic specification and sprouting, and we discuss exciting findings that shed new light on previously uncharacterized sources of lymphatic endothelial cells.
淋巴系统是一个盲端血管网络，在介导组织液稳态、肠道脂质吸收和免疫反应中发挥重要作用。深入了解淋巴管的发育以及控制其形成和形态发生的分子信号，可能对我们治疗淋巴相关疾病的能力至关重要。淋巴管的胚胎起源已经争论了一个多世纪，其中一种认为淋巴管内皮起源于静脉的模型占主导地位。然而，最近的研究为淋巴管的起源提供了新的见解。在这里，我们回顾了控制淋巴特化和出芽的分子机制，并讨论了一些令人兴奋的发现，这些发现为以前未被表征的淋巴管内皮细胞来源提供了新的线索。
