静脉注射海洛因滥用与急性心肌梗死：法医学研究
Intravenous Heroin Abuse and Acute Myocardial Infarction: Forensic Study.
作者信息
Pavlidis Pavlos, Deftereou Theodora-Eleftheria, Karakasi Maria-Valeria, Papadopoulos Nikolaos, Zissimopoulos Athanassios, Pagonopoulou Olga, Lambropoulou Maria
机构信息
From the Laboratories of *Forensic Sciences, †Histology-Embryology, ‡Nuclear Medicine, and §Physiology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
出版信息
Am J Forensic Med Pathol. 2016 Jun;37(2):95-8. doi: 10.1097/PAF.0000000000000224.
OBJECTIVE
The purpose of this study was to investigate chronic intravenous heroin abuse and its potential to induce acute myocardial infarction (AMI). It also aims to examine the causative factors and the incidence of heroin-induced myocardial infarction.
MATERIAL AND METHODS
The hearts of 113 intravenous heroin abusers were studied for a duration exceeding 3 years. The parameters studied included sex, age, time of intravenous heroin abuse, medical history, and body and heart weight. Macroscopic histological studies of the heart were also performed.
RESULTS
The histological examination revealed only 1 case of AMI. The victim was an intravenous heroin abuser for the last 7 years. The age and the medical history of the victim do not act as dissuading factors for the potential of an AMI.
CONCLUSIONS
The incidence of heroin-induced myocardial infarction is rare, and the actual mechanism remains unclear. The increased heart weight in relation to the increased thickness of the heart walls may be an aggravating factor, and thus, it is a fact that should be investigated.
目的
本研究旨在调查慢性静脉注射海洛因滥用情况及其诱发急性心肌梗死（AMI）的可能性。它还旨在研究海洛因诱发心肌梗死的致病因素和发病率。
材料与方法
对113名静脉注射海洛因滥用者的心脏进行了超过3年的研究。研究参数包括性别、年龄、静脉注射海洛因滥用时间、病史以及身体和心脏重量。还对心脏进行了宏观组织学研究。
结果
组织学检查仅发现1例急性心肌梗死病例。受害者是一名过去7年一直静脉注射海洛因的滥用者。受害者的年龄和病史并非急性心肌梗死发生可能性的劝阻因素。
结论
海洛因诱发心肌梗死的发病率很低，实际机制尚不清楚。心脏重量增加与心脏壁厚度增加可能是一个加重因素，因此，这是一个值得研究的事实。
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