Umraniye Training and Research Hospital, Istanbul - Turquia.
Van Egitim ve Arastirma Hastanesi, Van - Turquia.
Arq Bras Cardiol. 2020 Dec;115(6):1135-1141. doi: 10.36660/abc.20190296.
Heroin addiction is currently a significant health problem, and information on the electrocardiographic effects of heroin is limited.
The aim of the present study is to investigate effects of heroin addiction on electrocardiographic parameters.
A total of 136 individuals, including 66 individuals who smoke heroin as the study group and 70 healthy individuals with no drug addiction as the control group, were included in the study. Individuals who inject heroin were excluded. Electrocardiographic (ECG) evaluation of those using heroin was performed and compared with those of the control group. In addition, pre-treatment and post-treatment ECG of the heroin group were compared. A p-value of <0.05 was accepted as statistically significant.
Heart rate (77.2±12.8 versus 71.4±11.2; p=0.02) were found to be higher in the heroin group compared to the control group. QT (341.50±25.80 versus 379.11±45.23; p=0.01), QTc intervals (385.12±29.11 versus 411.3±51.70; p<0.01), and T peak to end time (Tpe) (65.41±10.82 versus 73.3±10.13; p<0.01) were significantly shorter in the heroin group. No difference was observed between the groups with regard to Tpe/QT and Tpe/QTc ratios. In the subgroup analysis of the heroin group, QT (356.81±37.49 versus 381.18±40.03; p<0.01) and QTc (382.06±26.41 versus 396.06±29.80; p<0.01) intervals were significantly shorter in the pre-treatment period.
Heroin addiction significantly affects the QT, QTc, and Tpe time intervals. The arrhythmia effects of these parameters are well known. More attention to the electrocardiographic parameters of these individuals should be given. (Arq Bras Cardiol. 2020; 115(6):1135-1141).
海洛因成瘾目前是一个严重的健康问题，有关海洛因对心电图影响的信息有限。
本研究旨在探讨海洛因成瘾对心电图参数的影响。
共纳入 136 名个体，包括 66 名作为研究组使用海洛因的个体和 70 名无吸毒史的健康个体作为对照组。排除使用海洛因注射的个体。对使用海洛因的个体进行心电图（ECG）评估，并与对照组进行比较。此外，比较了海洛因组的治疗前后的心电图。p 值<0.05 被认为具有统计学意义。
与对照组相比，海洛因组的心率（77.2±12.8 与 71.4±11.2；p=0.02）更高。QT（341.50±25.80 与 379.11±45.23；p=0.01）、QTc 间期（385.12±29.11 与 411.3±51.70；p<0.01）和 T 峰至末端时间（Tpe）（65.41±10.82 与 73.3±10.13；p<0.01）明显缩短。两组间 Tpe/QT 和 Tpe/QTc 比值无差异。在海洛因组的亚组分析中，QT（356.81±37.49 与 381.18±40.03；p<0.01）和 QTc（382.06±26.41 与 396.06±29.80；p<0.01）间期在治疗前明显缩短。
海洛因成瘾显著影响 QT、QTc 和 Tpe 时间间期。这些参数的心律失常作用是已知的。应该更加关注这些个体的心电图参数。（巴西心脏病学杂志。2020；115（6）：1135-1141）。
