Characteristics of Mongoloid populations and immunogenetics of various diseases based on the genetic markers of human immunoglobulins.

A clear genocline has been found for the distribution of Gm ag, Gm ab3st, and Gm afb1b3 haplotypes among the Mongoloid populations scattered in the world and characterized by the presence of four Gm haplotypes. Mongoloid populations are divided into two groups by an analysis of genetic distances and parametric multidimensional scaling: one is a northern group which is characterized by a high frequency of Gm ag and Gm ab3st and an extremely low frequency of Gm afb1b3 haplotype, and the other a southern group characterized by a remarkably high frequency of Gm afb1b3 and a low frequency of Gm ag and Gm ab3st haplotypes. The origin of the Gm afb1b3 characteristic of southern Mongoloids must exist in the Yunnan and Guangxi areas of southwest China. The origin of the Gm ab3st characteristic of northern Mongoloids must exist in Siberia, most likely in the Baikal area. The data which suggest the presence of Gm-associated pathogenic polygenes were obtained in the various diseases.