Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Strasse 31, 79104 Freiburg, Germany.
BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Nanomedicine (Lond). 2016 May;11(9):1017-30. doi: 10.2217/nnm.16.8. Epub 2016 Mar 17.
AIM: We synthesized ultra-small iron oxide nanoparticles (USPIONs) with tripod morphology and studied the effect of the aspect ratio (AR) of the tripod arms on mass magnetization, T2 relaxation and cytocompatibility in human cell lines. MATERIALS & METHODS: Tripods were prepared by controlling the temperature during the thermal decomposition of Fe(CO)5, and their magnetic properties were characterized by superconducting quantum interference device, and NMR. Citric acid stabilized USPIONs were used to assess cytocompatibility. RESULTS: T2 relaxivity of tripods showed dependency on AR of the tripod arm. Liver enzyme levels in presence of tripods were comparable to spherical USPIONs, and surprisingly tripods induced lower levels of reactive oxygen species. CONCLUSION: Tripod USPIONs with high AR arms possess excellent magnetic properties and cytocompatibility for further exploration as MRI contrast agents.
目的：我们合成了具有三脚架形态的超小氧化铁纳米粒子（USPIONs），并研究了三脚架支腿的纵横比（AR）对质量磁化、T2 弛豫和人细胞系细胞相容性的影响。
材料与方法：通过控制 Fe(CO)5 热分解过程中的温度来制备三脚架，并通过超导量子干涉装置和 NMR 对其磁性进行表征。使用柠檬酸稳定的 USPIONs 来评估细胞相容性。
结果：三脚架的 T2 弛豫率与三脚架支腿的 AR 有关。存在三脚架时的肝酶水平与球形 USPIONs 相当，令人惊讶的是，三脚架诱导的活性氧水平更低。
结论：具有高纵横比支腿的三脚架 USPIONs 具有优异的磁性能和细胞相容性，可进一步探索作为 MRI 造影剂。
Nanomedicine (Lond). 2016-3-17
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