Yamamoto Ryuichi, Kato Shingo, Maru Toshinori, Ninomiya Riki, Ozawa Fumiaki, Beck Yoshifumi, Abe Keiko, Tamaru Jun-Ichi, Nagoshi Sumiko, Yakabi Koji
Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Japan.
Intern Med. 2016;55(6):617-22. doi: 10.2169/internalmedicine.55.5761. Epub 2016 Mar 15.
We herein describe a case of somatostatinoma coexisting with a gastrointestinal stromal tumor (GIST) in the duodenum of an 81-year-old woman with Von Recklinghausen's disease (VRD) and common bile duct stone who presented with diarrhea of three months in duration. Gastroduodenoscopy revealed an ulcer on the second part of the duodenum. A 2.1-cm enhancing tumor was observed to extend from the ulcer on an abdominal computed tomography scan. Subtotal stomach-preserving pancreaticoduodenectomy revealed a somatostatinoma on the papilla of the vater and duodenal GIST. There have been only eight reports on VRD associated with ampullary somatostatinoma and GIST. An awareness of this possibility in patients with gastrointestinal lesions is necessary for proper treatment and patient management.
我们在此描述了一例81岁患有冯雷克林霍增氏病（VRD）、胆总管结石且持续腹泻三个月的女性十二指肠中生长抑素瘤与胃肠道间质瘤（GIST）共存的病例。胃十二指肠镜检查发现十二指肠第二部有溃疡。腹部计算机断层扫描显示一个2.1厘米的强化肿瘤从溃疡处延伸。保留胃的胰十二指肠次全切除术发现 Vater 乳头处有生长抑素瘤和十二指肠GIST。仅有八篇关于VRD合并壶腹生长抑素瘤和GIST的报告。对于胃肠道病变患者，认识到这种可能性对于正确治疗和患者管理是必要的。
