Doidge James C
Centre for Population Health Research, University of South Australia, Adelaide, Australia.
Stat Methods Med Res. 2018 Feb;27(2):352-363. doi: 10.1177/0962280216628902. Epub 2016 Mar 16.
Population-based cohort studies are invaluable to health research because of the breadth of data collection over time, and the representativeness of their samples. However, they are especially prone to missing data, which can compromise the validity of analyses when data are not missing at random. Having many waves of data collection presents opportunity for participants' responsiveness to be observed over time, which may be informative about missing data mechanisms and thus useful as an auxiliary variable. Modern approaches to handling missing data such as multiple imputation and maximum likelihood can be difficult to implement with the large numbers of auxiliary variables and large amounts of non-monotone missing data that occur in cohort studies. Inverse probability-weighting can be easier to implement but conventional wisdom has stated that it cannot be applied to non-monotone missing data. This paper describes two methods of applying inverse probability-weighting to non-monotone missing data, and explores the potential value of including measures of responsiveness in either inverse probability-weighting or multiple imputation. Simulation studies are used to compare methods and demonstrate that responsiveness in longitudinal studies can be used to mitigate bias induced by missing data, even when data are not missing at random.
基于人群的队列研究对健康研究非常重要,因为其随着时间推移收集的数据范围广泛,且样本具有代表性。然而,这类研究特别容易出现数据缺失的情况,当数据并非随机缺失时,可能会影响分析的有效性。多次进行数据收集为观察参与者随时间的反应性提供了机会,这可能有助于了解数据缺失机制,从而作为辅助变量发挥作用。在队列研究中,由于存在大量辅助变量和大量非单调缺失数据,诸如多重填补和最大似然法等现代处理缺失数据的方法可能难以实施。逆概率加权法可能更容易实施,但传统观点认为它不能应用于非单调缺失数据。本文描述了将逆概率加权法应用于非单调缺失数据的两种方法,并探讨了在逆概率加权法或多重填补中纳入反应性测量指标的潜在价值。通过模拟研究对这些方法进行比较,结果表明,即使数据并非随机缺失,纵向研究中的反应性也可用于减轻数据缺失导致的偏差。
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