Ravani Niraj Narendra, Katke Pramod H
Department of Psychiatry, Terna Medical College and Hospital, Navi Mumbai, Maharashtra, India.
Department of Pharmacology, Terna Medical College and Hospital, Navi Mumbai, Maharashtra, India.
Indian J Psychiatry. 2016 Jan-Mar;58(1):87-9. doi: 10.4103/0019-5545.174392.
Disorders of ejaculation are the consequences of surgical procedures and with the use of various drugs. Until date, most drugs reported to induce ejaculatory dysfunctions such as retrograde ejaculation or dry orgasms share the capacity to significantly antagonize alpha 1-adrenergic receptor. Iloperidone, a new dopamine Type 2 and serotonin Type 2A antagonist similar to risperidone, provides better efficacy with lesser extra-pyramidal side effects. In addition, it also antagonize alpha 1-adrenergic receptor and alpha-2C receptors. Limited data is available for iloperidone-induced ejaculation dysfunction. This article features five schizophrenic patients which developed retrograde ejaculation during treatment with iloperidone. The ejaculatory dysfunction following treatment with iloperidone could be postulated due to blocking of alpha 1-adrenergic receptor.
射精障碍是外科手术及使用各种药物的后果。迄今为止，大多数据报道可诱发射精功能障碍（如逆行射精或性高潮缺失）的药物都具有显著拮抗α1-肾上腺素能受体的能力。伊潘立酮是一种类似于利培酮的新型多巴胺2型和5-羟色胺2A型拮抗剂，疗效更佳，锥体外系副作用较少。此外，它还能拮抗α1-肾上腺素能受体和α-2C受体。关于伊潘立酮所致射精功能障碍的数据有限。本文介绍了5例在使用伊潘立酮治疗期间出现逆行射精的精神分裂症患者。伊潘立酮治疗后出现的射精功能障碍可能是由于α1-肾上腺素能受体受阻所致。
