Uluganyan Mahmut, Karaca Gurkan, Ulutas Turker Kemal, Ekmekci Ahmet, Tusun Eyup, Murat Ahmet, Koroglu Bayram, Uyarel Huseyin, Bakhshaliyev Nijad, Eren Mehmet
Clinic of Cardiology, Kadirli Government Hospital, Osmaniye, Turkey.
Clinic of Cardiology, Osmancik Government Hospital, Corum, Turkey.
J Clin Med Res. 2016 Apr;8(4):325-30. doi: 10.14740/jocmr2482w. Epub 2016 Feb 27.
The impact of Cockroft-Gault (C-G) derived estimated glomerular filtration rate (eGFR) on mortality and major adverse cardiac events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was assessed.
A total of 884 patients were classified into four categories according to admission creatine derived eGFR: < 60, 60 - < 90, 90 - < 120, and ≥ 120 mL/min/1.73 m(2).
In-hospital and long-term MACEs were significantly higher in eGFR < 60 mL/min/1.73 m(2) subgroup (P < 0.001 and P = 0.028). Multivariate analysis demonstrated 7.78-fold (95% CI: 0.91 - 66.8) higher mortality risk in eGFR < 60 mL/min/1.73 m(2) subgroup.
As an easily applicable bedside method, C-G derived eGFR could be important for prediction of in-hospital and long-term mortality and MACE in STEMI patients undergoing primary PCI.
评估了Cockcroft-Gault（C-G）公式估算的肾小球滤过率（eGFR）对接受直接经皮冠状动脉介入治疗（PCI）的ST段抬高型心肌梗死（STEMI）患者死亡率和主要不良心脏事件（MACE）的影响。
根据入院时肌酐得出的eGFR，将884例患者分为四类：<60、60 - <90、90 - <120和≥120 mL/（min/1.73 m²）。
eGFR<60 mL/（min/1.73 m²）亚组的住院期间和长期MACE显著更高（P<0.001和P = 0.028）。多变量分析显示，eGFR<60 mL/（min/1.73 m²）亚组的死亡风险高7.78倍（95% CI：0.91 - 66.8）。
作为一种易于应用的床旁方法，C-G公式得出的eGFR对于预测接受直接PCI的STEMI患者的住院期间和长期死亡率及MACE可能很重要。
