接受原发性放化疗的宫颈癌女性的放疗持续时间：一项基于人群的分析。
Radiation Duration in Women with Cervical Cancer Treated with Primary Chemoradiation: A Population-Based Analysis.
作者信息
Tergas Ana I, Neugut Alfred I, Chen Ling, Burke William M, Hershman Dawn L, Wright Jason D
机构信息
a Department of Obstetrics and Gynecology , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
b Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , NY , USA.
出版信息
Cancer Invest. 2016;34(3):137-47. doi: 10.3109/07357907.2015.1131291. Epub 2016 Mar 17.
This study examines factors associated with prolonged radiation duration and its impact on survival in women with cervical cancer treated with primary chemoradiation. Women in the National Cancer Database with stage IB2-IVA cervical cancer from 2003 to 2011 who received radiation and chemotherapy were included. Of 7209 women, who met inclusion criteria, 3401 (47.1%) and 3808 (52.8%) completed radiation in ≤ 8 and > 8 weeks, respectively. There was no overall survival difference for radiation duration ≤ 8 vs. > 8 weeks. Sensitivity analyses showed that inferior overall survival is only seen with radiation duration of > 10-12 weeks.
本研究探讨了与原发性放化疗治疗的宫颈癌女性患者放疗持续时间延长相关的因素及其对生存的影响。纳入了国家癌症数据库中2003年至2011年接受放疗和化疗的IB2-IVA期宫颈癌女性患者。在符合纳入标准的7209名女性中，分别有3401名（47.1%）和3808名（52.8%）在≤8周和>8周内完成了放疗。放疗持续时间≤8周与>8周的患者总生存率无差异。敏感性分析表明，仅在放疗持续时间>10 - 12周时观察到总生存率较差。
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