一项关于热带脾肿大综合征与氯喹预防的研究。

A study on tropical splenomegaly syndrome and chloroquine prophylaxis.

作者信息

Gupta O P, Bajaj S, Gupta S C

出版信息

J Assoc Physicians India. 1989 Sep;37(9):570-5.

Abstract

Forty-two adults (22 males, 20 females) with tropical splenomegaly syndrome (TSS) were studied. Majority (88.1%) presented with complaints related to grossly enlarged spleen (greater than 10 cm). The duration of splenomegaly was 1 to 5 years in 54.8%. In 80.9% there was anaemia (Hb less than 10 g%). None of the patients had a macrocytic blood picture. Evidence of portal hypertension was observed in 56.7% and almost a similar number (58.1%) had raised intrasplenic pressure. The liver histology was entirely normal in only 8.8%. T-cell lymphopenia with B-cell lymphocytosis was a prominent feature. IgM values were raised in 73.8% and malarial antibody titres in 91.7% patients. Sixty-nine per cent of cases showed a distinct clinical and biochemical improvement after chloroquine chemoprophylaxis. Though a malarial origin in the development of TSS is favoured its precise aetiology is as yet speculative.

摘要

对42例热带脾肿大综合征（TSS）成人患者（22例男性，20例女性）进行了研究。大多数患者（88.1%）表现出与脾脏明显肿大（大于10厘米）相关的症状。54.8%的患者脾肿大持续时间为1至5年。80.9%的患者有贫血（血红蛋白低于10克%）。所有患者均无大细胞性血象。56.7%的患者有门静脉高压的证据，几乎相同比例（58.1%）的患者脾内压升高。仅8.8%的患者肝脏组织学完全正常。T细胞淋巴细胞减少伴B细胞淋巴细胞增多是一个突出特征。73.8%的患者IgM值升高，91.7%的患者疟疾抗体滴度升高。69%的病例在氯喹化学预防后显示出明显的临床和生化改善。尽管TSS的发展倾向于疟疾起源，但其确切病因仍具有推测性。