Fakunle Y M, Oduloju A J, Greenwood B M
Clin Exp Immunol. 1978 Aug;33(2):239-43.
Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the percentage and number of B-lymphocytes. These abnormalities reverted towards normal on treatment. Splenic aspirates contained an increased proportion of T-lymphocytes. The relative T-cell lymphoenia in TSS is probably due to specific trapping or non-specific sequestration of lymphocytes in the liver and splen. B-cell lymphocytosis is probably due to persistent antigenic or mitogenic stimulation by malaria.
采用E花环、EAC花环及直接免疫荧光染色技术，对39例热带脾肿大综合征（TSS）患者的淋巴细胞亚群进行了研究。在外周血中，发现T淋巴细胞百分比下降，同时B淋巴细胞百分比及数量增加。这些异常在治疗后恢复正常。脾穿刺液中T淋巴细胞比例增加。TSS中相对的T细胞减少可能是由于淋巴细胞在肝脏和脾脏中特异性捕获或非特异性隔离所致。B细胞淋巴细胞增多可能是由于疟疾持续的抗原性或促有丝分裂刺激所致。
