成年哺乳动物大脑中神经前体细胞的多样性
Diversity of Neural Precursors in the Adult Mammalian Brain.
作者信息
Bonaguidi Michael A, Stadel Ryan P, Berg Daniel A, Sun Jiaqi, Ming Guo-li, Song Hongjun
机构信息
Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685.
Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Human Genetics Predoctoral Program, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
Cold Spring Harb Perspect Biol. 2016 Apr 1;8(4):a018838. doi: 10.1101/cshperspect.a018838.
Abstract
Aided by advances in technology, recent studies of neural precursor identity and regulation have revealed various cell types as contributors to ongoing cell genesis in the adult mammalian brain. Here, we use stem-cell biology as a framework to highlight the diversity of adult neural precursor populations and emphasize their hierarchy, organization, and plasticity under physiological and pathological conditions.
摘要
在技术进步的辅助下，最近关于神经前体特征和调控的研究揭示了多种细胞类型是成年哺乳动物大脑中持续细胞生成的贡献者。在这里，我们以干细胞生物学为框架，突出成年神经前体群体的多样性，并强调它们在生理和病理条件下的层级、组织和可塑性。
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