血清阴性的母亲重症肌无力和迟发性短暂性新生儿重症肌无力
Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis.
作者信息
Townsel Courtney, Keller Rebecca, Johnson Kendall, Hussain Naveed, Campbell Winston A
机构信息
Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Division of Neonatology, Connecticut Children's Medical Center, Farmington, Connecticut.
出版信息
AJP Rep. 2016 Mar;6(1):e133-6. doi: 10.1055/s-0036-1579624.
Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We present a case of seronegative maternal ocular MG and delayed TNMG. Case A 29-year-old G3P1011 underwent cesarean birth of a male infant who developed oxygen desaturation requiring supplemental oxygen on day of life (DOL) 3. Based on the clinical course and after exclusion of other diagnoses, the infant was diagnosed with TNMG. Infant's condition improved spontaneously and he was weaned off supplemental oxygen and discharged home on DOL 12. Conclusion Infants born to mothers with seronegative localized (ocular) MG are also susceptible to TNMG which may be late in onset.
背景
重症肌无力（MG）是一种自身免疫性疾病，表现为肌肉无力波动，分为全身型和局限型（眼肌型）。母体抗乙酰胆碱受体抗体可穿过胎盘，可能导致短暂性新生儿重症肌无力（TNMG）。我们报告一例血清学阴性的母体眼肌型MG及延迟性TNMG病例。病例：一名29岁、孕3产1、有1次流产史、1次早产史的产妇行剖宫产分娩一名男婴，该男婴在出生第3天出现氧饱和度下降，需要吸氧。根据临床病程并排除其他诊断后，该婴儿被诊断为TNMG。婴儿病情自发改善，在出生第12天停用补充氧气并出院回家。结论：血清学阴性的局限型（眼肌型）MG母亲所生的婴儿也易患TNMG，且可能发病较晚。
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