Masra Farin, Ishak Shareena, Cheah Fook-Choe
Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Cheras, Kuala Lumpur, Malaysia.
Turk J Pediatr. 2023;65(2):321-325. doi: 10.24953/turkjped.2022.717.
Transient neonatal myasthenia gravis (TNMG) is an acquired disease which occurs in 10 to 20% of infants born to a mother with myasthenia gravis. Even though it is a self-limiting disorder, it may potentially be life-threatening if prompt diagnosis is not made, and expedient supportive respiratory management is not initiated when required.
Here we describe three infants with TNMG. Two of them developed symptoms of TNMG within 24 hours of life, but one developed symptoms at 43 hours of life. One of the patients had an atypical form of TNMG with contracture and hypotonia. The other two infants survived a typical form of TNMG with hypotonia and poor sucking. All cases resolved spontaneously by one to two weeks of life with conservative management.
Infants born to mothers with myasthenia gravis need to be monitored closely for symptoms of TNMG for the first 48 to 72 hours of life. However, the majority of infants with TNMG traverse a benign course and resolve spontaneously with expectant care.
短暂性新生儿重症肌无力（TNMG）是一种后天性疾病，发生于患有重症肌无力的母亲所生的10%至20%的婴儿中。尽管它是一种自限性疾病，但如果不能及时诊断，且在需要时不立即进行适当的支持性呼吸管理，可能会危及生命。
我们在此描述3例TNMG患儿。其中2例在出生后24小时内出现TNMG症状，但1例在出生43小时后出现症状。1例患者患有非典型TNMG，伴有挛缩和肌张力减退。另外2例婴儿患有典型的TNMG，伴有肌张力减退和吸吮无力。所有病例通过保守治疗在出生后1至2周内自然缓解。
患有重症肌无力的母亲所生的婴儿在出生后的头48至72小时内需密切监测TNMG症状。然而，大多数TNMG婴儿病程良性，通过观察护理可自然缓解。
