Mna Amira Ben, Souissi Asmahene, Halouani Slim, El Euch Dalenda, Zahani Alia, Kchir Nidham, Zaraa Ines, Mokni Mourad
La Rabta Hospital.
Dermatol Online J. 2016 Jan 15;22(1):13030/qt7rm8h9n3.
Methotrexate-induced cutaneous ulceration is a rare but potentially serious drug adverse reaction. This adverse reaction of methotrexate therapy has been initially described in psoriasis patients and is unusual in patients with cutaneous T-cell lymphoma. In 1978, Mc Donald et al reported the first three cases of cutaneous ulcerations in patients treated for a mycosis fungoides with intravenous infusions of methotrexate. Since then, few cases of methotrexate-induced skin ulcers in patients with mycosis fungoides have been published. We report an additional patient with erythrodermic mycosis fungoides who developed cutaneous ulcerations as a sole manifestation of methotrexate toxicity.
甲氨蝶呤所致皮肤溃疡是一种罕见但可能严重的药物不良反应。甲氨蝶呤治疗的这种不良反应最初在银屑病患者中被描述，在皮肤T细胞淋巴瘤患者中并不常见。1978年，麦克唐纳等人报告了首例3例用甲氨蝶呤静脉输注治疗蕈样肉芽肿的患者出现皮肤溃疡的病例。从那时起，关于蕈样肉芽肿患者中甲氨蝶呤引起皮肤溃疡的病例报道很少。我们报告了另外1例红皮病型蕈样肉芽肿患者，该患者出现皮肤溃疡，这是甲氨蝶呤毒性的唯一表现。
