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奥克塔baix研究:对西班牙85岁社区房颤患者进行三年随访后的高死亡率

High rate of mortality in Spanish community-dwelling population aged 85 with atrial fibrillation after three years of follow-up: The Octabaix study.

作者信息

Formiga Francesc, Ferrer Assumpta, Mestre Delia, Brasé Ariadna, Soldevila Laura, Corbella Xavier

机构信息

Geriatric Unit, Internal Medicine Service, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Primary Healthcare Centre 'El Plà' CAP -I, Sant Feliu de Llobregat, Barcelona, Spain.

出版信息

Australas J Ageing. 2016 Sep;35(3):216-9. doi: 10.1111/ajag.12261. Epub 2016 Mar 15.

Abstract

AIM

To assess the possible association between three-year global mortality and atrial fibrillation (AF) in 328 community-dwelling participants aged 85 at baseline.

METHODS

Sociodemographic data, comorbidity and geriatric assessment tools, thromboembolic risk, and AF therapy were assessed. We compared the patients who survived with those who died.

RESULTS

At baseline, 41 (12.5%) of participants had permanent AF, and 13 of them died (31.7%) after the three-year follow-up period compared with 44 (15.3%) of the rest of cohort (P = 0.01). Cox regression analysis identified two significant clinical variables as independent predictors of three-year risk of global mortality: Lawton Index (hazard ratio 0.82, 95% confidence interval 0.75-0.91) and AF (hazard ratio 1.90, 95% confidence interval 1.01-3.56). None of the other of variables evaluated showed predictive value of global mortality in the AF patients.

CONCLUSION

In oldest old community-dwelling participants, AF is an independent risk factor for global mortality after a three-year follow-up period.

摘要

目的

评估328名基线年龄为85岁的社区居住参与者的三年全因死亡率与心房颤动(AF)之间的可能关联。

方法

评估社会人口统计学数据、合并症和老年评估工具、血栓栓塞风险以及房颤治疗情况。我们比较了存活患者和死亡患者。

结果

在基线时,41名(12.5%)参与者患有永久性房颤,其中13名(31.7%)在三年随访期后死亡,而队列其余部分有44名(15.3%)死亡(P = 0.01)。Cox回归分析确定了两个显著的临床变量作为三年全因死亡风险的独立预测因素:劳顿指数(风险比0.82,95%置信区间0.75 - 0.91)和房颤(风险比1.90,95%置信区间1.01 - 3.56)。评估的其他变量在房颤患者中均未显示出全因死亡率的预测价值。

结论

在最年长的社区居住参与者中,房颤是三年随访期后全因死亡的独立危险因素。

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