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生物活性化合物靶标鉴定的综合分析方法:MorphoBase 和 ChemProteoBase。

Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.

机构信息

Chemical Biology Research Group, RIKEN CSRS, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

出版信息

Nat Prod Rep. 2016 May 4;33(5):621-5. doi: 10.1039/c5np00106d.

Abstract

Covering: up to the end of 2015.Many useful compounds from natural products have been discovered through phenotype-based screening. However, the target identification process for compounds is laborious and time-consuming. With the development of new equipment and methodologies for biological analyses, a variety of profiling methods that utilize large sets of experimental data have been established. Here, we highlight the utility of our identification approaches, MorphoBase and ChemProteoBase.

摘要

涵盖范围

截至 2015 年底。通过基于表型的筛选,已经发现了许多来自天然产物的有用化合物。然而,化合物的靶标鉴定过程既费力又耗时。随着生物分析新设备和新方法的发展,已经建立了各种利用大量实验数据的剖析方法。在这里,我们强调了我们的鉴定方法 MorphoBase 和 ChemProteoBase 的实用性。

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