Department of Dermatology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
Department of Pathology, Hospital del Mar, Passeig Marítim, 25-29, ES-08003, Barcelona, Spain.
Br J Dermatol. 2016 Nov;175(5):1052-1055. doi: 10.1111/bjd.14571. Epub 2016 Jul 5.
Localized cutaneous argyria is a rare condition secondary to skin deposition of silver following exposure to substances containing this metal. The clinical appearance and dermoscopy findings require deep melanocytic lesions and particularly melanoma metastasis to be ruled out. Silver deposits are usually confirmed by scanning electron microscopy and/or energy-dispersive X-ray spectroscopy. Herein we describe the in vivo reflectance confocal microscopy (RCM) features observed in one case of localized cutaneous argyria. These features include the presence of a hyperrefractile network in the papillary dermis and a periadnexal dotted bright pattern. In vivo RCM might be a useful tool for an early diagnosis of this uncommon entity.
局限性皮肤银质沉着症是一种罕见的疾病，主要是由于皮肤接触含有这种金属的物质后，银在皮肤中沉积所致。临床表现和皮肤镜检查结果需要排除深部黑色素瘤病变，尤其是黑色素瘤转移。银沉积通常通过扫描电子显微镜和/或能量色散 X 射线光谱来确认。在此，我们描述了 1 例局限性皮肤银质沉着症的体内反射共聚焦显微镜（RCM）特征。这些特征包括在乳头真皮中存在高折射网络和附属器周围点状明亮模式。体内 RCM 可能是早期诊断这种罕见疾病的有用工具。
