用微透析法测定大鼠血液和肾皮质中作为食品掺假物的马来酸的药代动力学
Pharmacokinetics of Maleic Acid as a Food Adulterant Determined by Microdialysis in Rat Blood and Kidney Cortex.
作者信息
Hou Mei-Ling, Lu Chia-Ming, Lin Chi-Hung, Lin Lie-Chwen, Tsai Tung-Hu
机构信息
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, Beitou District, Taipei 11221, Taiwan.
Institute of Microbiology and Immunology, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, Beitou District, Taipei 11221, Taiwan.
出版信息
Molecules. 2016 Mar 17;21(3):367. doi: 10.3390/molecules21030367.
Maleic acid has been shown to be used as a food adulterant in the production of modified starch by the Taiwan Food and Drug Administration. Due to the potential toxicity of maleic acid to the kidneys, this study aimed to develop an analytical method to investigate the pharmacokinetics of maleic acid in rat blood and kidney cortex. Multiple microdialysis probes were simultaneously inserted into the jugular vein and the kidney cortex for sampling after maleic acid administration (10 or 30 mg/kg, i.v., respectively). The pharmacokinetic results demonstrated that maleic acid produced a linear pharmacokinetic phenomenon within the doses of 10 and 30 mg/kg. The area under concentration versus time curve (AUC) of the maleic acid in kidney cortex was 5-fold higher than that in the blood after maleic acid administration (10 and 30 mg/kg, i.v., respectively), indicating that greater accumulation of maleic acid occurred in the rat kidney.
台湾食品药品管理部门已证实马来酸在变性淀粉生产中被用作食品掺假物。由于马来酸对肾脏具有潜在毒性，本研究旨在开发一种分析方法，以研究马来酸在大鼠血液和肾皮质中的药代动力学。在静脉注射马来酸（分别为10或30mg/kg）后，将多个微透析探针同时插入颈静脉和肾皮质进行采样。药代动力学结果表明，在10至30mg/kg剂量范围内，马来酸呈现线性药代动力学现象。静脉注射马来酸（分别为10和30mg/kg）后，肾皮质中马来酸的浓度-时间曲线下面积（AUC）比血液中的高5倍，这表明马来酸在大鼠肾脏中的蓄积量更大。
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