3.0 特斯拉磁共振成像评估听神经病谱系障碍患者的蜗神经直径和横截面积
Evaluation of cochlear nerve diameter and cross-sectional area in ANSD patients by 3.0-Tesla MRI.
作者信息
Peng Liyan, Xiao Yunfei, Liu Lei, Mao Zhongyao, Chen Qingguo, Zhou Liangqiang, Liao Bo, Liu Aiguo, Wang Xinglong
机构信息
a Department of Otorhinolaryngology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
b Department of Radiology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China ;
出版信息
Acta Otolaryngol. 2016 Aug;136(8):792-9. doi: 10.3109/00016489.2016.1159329. Epub 2016 Mar 22.
CONCLUSIONS
The size of cochlear nerve (CN) is atrophic in adult auditory neuropathy spectrum disorder (ANSD) patients compared with non-ANSD sensorineural hearing loss (SNHL) patients and normal hearing subjects, and CN deficiency is one of the lesions for ANSD patients.
OBJECTIVES
To evaluate the dimensions of CN in adult ANSD patients on magnetic resonance imaging (MRI) and confirm the hypothesis that CN deficiency is one of the lesions for ANSD patients.
METHODS
Medical records and MRI of 24 adult ANSD patients reviewed retrospectively and 20 non-ANSD SNHL and 24 volunteers with normal hearing were recruited as control groups. The long diameter (LD), short diameter (SD), and cross-sectional area (CSA) of CN and facial nerve (FN) were measured.
RESULTS
Among the 24 ANSD patients, this study was able to reconstruct and measure the CN of 91.7% (22/24, total 43 ears) of patients and FN of 83.3% (20/24, total 38 ears) of patients. The mean values and standard deviations of LD, SD, and CSA of CN in ANSD patients were 0.65 ± 0.20 mm, 0.44 ± 0.15 mm, and 0.30 ± 0.19 mm(2), respectively. They were significantly smaller in ANSD patients than in control groups (p < 0.001).
结论
与非听觉神经病谱系障碍（ANSD）的感音神经性听力损失（SNHL）患者及听力正常的受试者相比，成年ANSD患者的蜗神经（CN）尺寸萎缩，且CN缺失是ANSD患者的病变之一。
目的
在磁共振成像（MRI）上评估成年ANSD患者的CN尺寸，并证实CN缺失是ANSD患者病变之一的假设。
方法
回顾性分析24例成年ANSD患者的病历及MRI资料，并招募20例非ANSD的SNHL患者和24例听力正常的志愿者作为对照组。测量CN及面神经（FN）的长径（LD）、短径（SD）和横截面积（CSA）。
结果
在24例ANSD患者中，本研究能够重建并测量91.7%（22/24，共43耳）患者的CN及83.3%（20/24，共38耳）患者的FN。ANSD患者CN的LD、SD和CSA的平均值及标准差分别为0.65±0.20mm、0.44±0.15mm和0.30±0.19mm²。ANSD患者的这些数值显著小于对照组（p<0.001）。
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