Fasano M L, Soro S, Ferrara L A
Institute of Internal Medicine and Metabolic Diseases, University of Naples, Italy.
Drugs Exp Clin Res. 1989;15(11-12):587-90.
The long-term antihypertensive efficacy of a combination of ketanserin (20 mg), an S2 antagonist with alpha 1 blocking activity, and chlorthalidone (25 mg), given o.d., was evaluated in fifteen patients with primary hypertension of mild to moderate degree, aged 45-65 years, up to a 12-month observation period. Systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were measured by an automatic recorder (Sentron Bard Biomedical) twice at rest after 5 min in a supine position and after 2 and 5 min in an upright position, 24 h after the last antihypertensive dose. Thirteen patients completed the study whilst two were lost to the follow-up. A significant reduction was observed in both SBP and DBP at rest. In particular, SBP was reduced from 167 +/- 17 mmHg to 152 +/- 21 mmHg (p less than 0.01) after 1 month of therapy and was kept constant at this level throughout the observation period. DBP was also reduced from the first control [99 +/- 7 vs. 90 +/- 9 mmHg (p less than 0.01)] without any increase during the follow-up. HR was unchanged throughout the study. Four patients had dizziness and orthostatic hypotension after the first dose of the drug combination but were able to continue the study without further adverse reactions. These data support the conclusion that long-term treatment with the combination of a small dose of ketanserin and chlorthalidone is able to reduce systolic and diastolic blood pressure, without remarkable untoward side-effects.
对15例年龄在45 - 65岁、轻度至中度原发性高血压患者，评估了酮色林（20毫克）（一种具有α1阻断活性的S2拮抗剂）与氯噻酮（25毫克）每日一次联合用药的长期降压疗效，观察期长达12个月。在末次服用抗高血压药物24小时后，使用自动记录仪（Sentron Bard Biomedical），让患者仰卧位休息5分钟后、站立位2分钟和5分钟后，测量收缩压（SBP）、舒张压（DBP）和心率（HR），各测量两次。13例患者完成了研究，2例失访。静息时SBP和DBP均显著降低。具体而言，治疗1个月后SBP从167±17 mmHg降至152±21 mmHg（p<0.01），并在整个观察期内维持在该水平。DBP也从首次对照时的99±7 mmHg降至90±9 mmHg（p<0.01），随访期间未再升高。整个研究过程中HR未变。4例患者在首次服用联合药物后出现头晕和体位性低血压，但能够继续研究且未出现进一步不良反应。这些数据支持以下结论：小剂量酮色林与氯噻酮联合长期治疗能够降低收缩压和舒张压，且无明显不良副作用。
