成纤维细胞生长因子23（FGF - 23）水平因工业化程度不同而在不同人群中存在差异。
Fibroblast Growth Factor-23 (FGF-23) Levels Differ Across Populations by Degree of Industrialization.
作者信息
Yuen Shennin N, Kramer Holly, Luke Amy, Bovet Pascal, Plange-Rhule Jacob, Forrester Terrence, Lambert Vicki, Wolf Myles, Camacho Pauline, Harders Regina, Dugas Lara, Cooper Richard, Durazo-Arvizu Ramon
机构信息
Departments of Public Health Sciences (S.N.Y., H.K., A.L., R.H., L.D., R.C., R.D.-A.) and Medicine (H.K.), Division of Nephrology and Hypertension, and Division of Endocrinology (P.C.), Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153; Institute of Social and Preventive Medicine (P.B.), Division of Chronic Disease, Biopole 2, Bureau no. 01-171, 1010 Lausanne, Switzerland; Ministry of Health (P.B.), Victoria, Republic of Seychelles; School of Medical Sciences, Kwame Nkrumah University of Science and Technology (J.P.-R.), Kumasi, Ghana; Tropical Medicine Research Institute (T.F.), University of the West Indies, Solutions for Developing Countries, Mona, Kingston 7, Jamaica; Department of Human Biology (V.L.), Division of Exercise Science and Sports Medicine, Division of Exercise Science and Sports Medicine Department of Human Biology, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, 7725 Cape Town, South Africa and Institute of Public Health Sciences (M.W.), Northwestern Medical Center, Chicago, Illinois 60208.
出版信息
J Clin Endocrinol Metab. 2016 May;101(5):2246-53. doi: 10.1210/jc.2015-3558. Epub 2016 Mar 22.
CONTEXT
Compensatory increases in fibroblast growth factor 23 (FGF23) with increasing phosphate intake may adversely impact health. However, population and clinical studies examining the link between phosphate intake and FGF23 levels have focused mainly on populations living in highly industrialized societies in which phosphate exposure may be homogenous.
OBJECTIVE
The objective of the study was to contrast dietary phosphate intake, urinary measures of phosphate excretion, and FGF23 levels across populations that differ by the level of industrialization.
DESIGN
This was a cross-sectional analysis of three populations.
SETTING
The study was conducted in Maywood, Illinois; Mahé Island, Seychelles; and Kumasi, Ghana.
PARTICIPANTS
Adults with African ancestry aged 25-45 years participated in the study.
MAIN OUTCOME
FGF23 levels were measured.
RESULTS
The mean age was 35.1 (6.3) years and 47.9% were male. Mean phosphate intake and fractional excretion of phosphate were significantly higher in the United States vs Ghana, whereas no significant difference in phosphate intake or fractional excretion of phosphate was noted between the United States and Seychelles for men or women. Overall, median FGF23 values were 57.41 RU/mL (interquartile range [IQR] 43.42, 75.09) in the United States, 42.49 RU/mL (IQR 33.06, 55.39) in Seychelles, and 33.32 RU/mL (IQR 24.83, 47.36) in Ghana. In the pooled sample, FGF23 levels were significantly and positively correlated with dietary phosphate intake (r = 0.11; P < .001) and the fractional excretion of phosphate (r = 0.13; P < .001) but not with plasma phosphate levels (r = -0.001; P = .8). Dietary phosphate intake was significantly and positively associated with the fractional excretion of phosphate (r = 0.23; P < .001).
CONCLUSION
The distribution of FGF23 levels in a given population may be influenced by the level of industrialization, likely due to differences in access to foods preserved with phosphate additives.
背景
随着磷摄入量增加，成纤维细胞生长因子23（FGF23）的代偿性升高可能会对健康产生不利影响。然而，研究磷摄入量与FGF23水平之间联系的人群和临床研究主要集中在高度工业化社会的人群，在这些社会中磷暴露可能是均匀的。
目的
本研究的目的是对比不同工业化水平人群的膳食磷摄入量、尿磷排泄指标和FGF23水平。
设计
这是对三个人群的横断面分析。
地点
研究在伊利诺伊州梅伍德、塞舌尔马埃岛和加纳库马西进行。
参与者
年龄在25 - 45岁之间的非洲裔成年人参与了研究。
主要结果
测量FGF23水平。
结果
平均年龄为35.1（6.3）岁，47.9%为男性。美国的平均磷摄入量和磷分数排泄显著高于加纳，而美国和塞舌尔的男性或女性在磷摄入量或磷分数排泄方面没有显著差异。总体而言，美国的FGF23中位数为57.41 RU/mL（四分位间距[IQR] 43.42，75.09），塞舌尔为42.49 RU/mL（IQR 33.06，55.39），加纳为33.32 RU/mL（IQR 24.83，47.36）。在汇总样本中，FGF23水平与膳食磷摄入量（r = 0.11；P <.001）和磷分数排泄（r = 0.13；P <.001）显著正相关，但与血浆磷水平无关（r = -0.001；P =.8）。膳食磷摄入量与磷分数排泄显著正相关（r = 0.23；P <.001）。
结论
特定人群中FGF23水平的分布可能受工业化水平影响，可能是由于获取含磷添加剂保存食品的机会不同。
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