慢性复发性伏格特-小柳-原田病及“晚霞样眼底”的出现预示视网膜敏感性更差。
Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity.
作者信息
Abu El-Asrar Ahmed M, Al Mudhaiyan Tariq, Al Najashi AlHatoon A, Hemachandran Suhail, Hariz Rajab, Mousa Ahmed, Al-Muammar Abdulrahman
机构信息
a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
b Dr Nasser Al-Rashid Research Chair in Ophthalmology.
出版信息
Ocul Immunol Inflamm. 2017 Aug;25(4):475-485. doi: 10.3109/09273948.2016.1139730. Epub 2016 Mar 22.
PURPOSE
To investigate prognostic factors for retinal sensitivity assessed by microperimetry in patients with Vogt-Koyanagi-Harada (VKH) disease.
METHODS
In total, 34 patients with initial-onset acute disease and 19 patients with chronic recurrent disease were retrospectively evaluated.
RESULTS
The mean follow-up period was 40.4 ± 40.5 months. Sensitivity was significantly worse in eyes with more severe anterior segment inflammation at presentation, as indicated by the presence of mutton-fat keratic precipitates, anterior chamber reaction ≥2+, and posterior synechiae. Chronic recurrent presentation, development of complications, and 'sunset glow fundus' were significantly associated with worse sensitivity. Using logistic regression analysis, better sensitivity was significantly associated with initial-onset acute presentation (odds ratio, OR = 6.9; 95% confidence interval, CI = 1.53-9.66).
CONCLUSIONS
Chronic recurrent presentation and development of complications and 'sunset glow fundus' are associated with a worse sensitivity outcome.
目的
研究伏格特-小柳-原田（VKH）病患者通过微视野计评估的视网膜敏感性的预后因素。
方法
回顾性评估了总共34例初发急性病患者和19例慢性复发性疾病患者。
结果
平均随访期为40.4±40.5个月。出现羊脂状角膜后沉着物、前房反应≥2+和虹膜后粘连表明，就诊时前段炎症更严重的眼睛的敏感性明显更差。慢性复发性表现、并发症的发生以及“晚霞样眼底”与较差的敏感性显著相关。使用逻辑回归分析，更好的敏感性与初发急性表现显著相关（优势比，OR = 6.9；95%置信区间，CI = 1.53 - 9.66）。
结论
慢性复发性表现、并发症的发生以及“晚霞样眼底”与较差的敏感性结果相关。
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