Ueda M, Teranishi Y, Kitamura T, Makigusa K, Shirai T, Tanaka M, Higashi K, Ohashi S, Minamibayashi S, Yamaoka A
Nihon Shishubyo Gakkai Kaishi. 1989 Mar;31(1):288-98. doi: 10.2329/perio.31.288.
Three different sites which have more than 5 mm pocket were randomly selected in each periodontal patient and were divided into three groups: PT-01 treated site, placebo treated site and control site. After application of either PT-01 or placebo twice for two weeks, subgingval scaling and root planing were performed. Then PT-01 and the placebo were applied weekly to the periodontal pocket for four weeks and clinical and microbiological evaluations were made. The results obtained were as follows: 1. On clinical evaluation, significant improvement was found in the PT-01 treated site in comparison with the placebo treated and/or control site. 2. On microbiological evaluation, slight improvement was found in the PT-01 treated site, whereas there was no significant difference among the three sites.
在每位牙周炎患者中随机选择三个袋深超过5毫米的不同部位，并分为三组：PT - 01治疗部位、安慰剂治疗部位和对照部位。在PT - 01或安慰剂每日两次应用两周后，进行龈下刮治和根面平整。然后每周在牙周袋内应用PT - 01和安慰剂，持续四周，并进行临床和微生物学评估。得到的结果如下：1. 在临床评估中，与安慰剂治疗部位和/或对照部位相比，PT - 01治疗部位有显著改善。2. 在微生物学评估中，PT - 01治疗部位有轻微改善，而三个部位之间无显著差异。
