[Influence of pirenzepine on bronchial reactivity evaluated by the methacholine provocation test in a double-blind study of patients with bronchial asthma].

A double blind study was carried out on the effect of pirenzepine on bronchial reactivity assessed by metacholine provocation. The study was carried out on 19 patients with bronchial asthma. Bronchial provocation tests was performed according to the method of Ryan et al using the DeVilbis 646 nebuliser coupled to the Rosenthal--French dosimeter. Spirometric parameters were assessed using Vitalograph. The results show a significant protective effect of pirenzepine on bronchial spasm induced by metacholine.