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色甘酸钠对变应原诱导的支气管收缩和高反应性增加的保护作用:一项双盲安慰剂对照研究。

Protective effect of disodium cromoglycate on allergen-induced bronchoconstriction and increased hyperresponsiveness: a double-blind placebo-controlled study.

作者信息

Mattoli S, Foresi A, Corbo G M, Polidori G, Ciappi G

出版信息

Ann Allergy. 1986 Oct;57(4):295-300.

PMID:3094411
Abstract

The protective effect of 40 mg cromolyn on allergen-induced late response and increased hyperresponsiveness were studied in five asthmatic children to whom this drug and saline placebo were administered 20 minutes before allergen inhalation, at random, double-blind. Cromolyn reduced the magnitude of early and late responses and abolished the increase in methacholine responsiveness.

摘要

在5名哮喘儿童中研究了40毫克色甘酸钠对变应原诱导的迟发反应和高反应性增加的保护作用。在吸入变应原前20分钟,对这些儿童随机、双盲给予该药物和生理盐水安慰剂。色甘酸钠降低了早发和迟发反应的程度,并消除了乙酰甲胆碱反应性的增加。

相似文献

1
Protective effect of disodium cromoglycate on allergen-induced bronchoconstriction and increased hyperresponsiveness: a double-blind placebo-controlled study.色甘酸钠对变应原诱导的支气管收缩和高反应性增加的保护作用:一项双盲安慰剂对照研究。
Ann Allergy. 1986 Oct;57(4):295-300.
2
Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine.色甘酸钠对支气管哮喘患者的治疗作用。对过敏原、组胺和乙酰甲胆碱吸入激发试验的影响。
JAMA. 1976 Aug 23;236(8):927-31.
3
Sodium cromoglycate-induced changes in the dose-response curve of inhaled methacholine and histamine in asthmatic children.
Am Rev Respir Dis. 1979 Jun;119(6):927-32. doi: 10.1164/arrd.1979.119.6.927.
4
[Effect of fenoterol and disodium cromoglycate on the methacholine provocation test in bronchial asthma].
Prax Klin Pneumol. 1986 May;40(5):167-72.
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Effect of inhaled furosemide and cromolyn on bronchoconstriction induced by ultrasonically nebulized distilled water in asthmatic subjects.吸入速尿和色甘酸钠对哮喘患者超声雾化蒸馏水诱发支气管收缩的影响。
Ann Allergy Asthma Immunol. 1997 Feb;78(2):238-43. doi: 10.1016/S1081-1206(10)63395-9.
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Effect of nisoldipine (BAY k 5552) on methacholine-induced bronchoconstriction in patients with nonspecific bronchial hyperreactivity.尼索地平(BAY k 5552)对非特异性支气管高反应性患者中乙酰甲胆碱诱发的支气管收缩的影响。
Ann Allergy. 1989 Dec;63(6 Pt 1):498-502.
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Effect of nifedipine on allergen-induced bronchoconstriction.硝苯地平对变应原诱导的支气管收缩的作用。
Allergol Immunopathol (Madr). 1986 Jul-Aug;14(4):263-8.
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[Protective effect of ketotifen and disodium cromoglycate in bronchial challenge tests with allergens (author's transl)].酮替芬和色甘酸钠在变应原支气管激发试验中的保护作用(作者译)
Dtsch Med Wochenschr. 1980 Sep 19;105(38):1313-5. doi: 10.1055/s-2008-1070862.
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Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma.VLA-4拮抗剂IVL745对哮喘患者变应原诱导的支气管收缩的影响。
J Allergy Clin Immunol. 2005 Oct;116(4):761-7. doi: 10.1016/j.jaci.2005.04.045. Epub 2005 Aug 19.
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A comparison of the inhibitory effects of ketotifen and disodium cromoglycate on bronchial responses to house dust, with special reference to the late asthmatic response.酮替芬与色甘酸钠对支气管对屋尘反应的抑制作用比较,特别提及迟发性哮喘反应。
Pharmatherapeutica. 1984;4(1):36-42.

引用本文的文献

1
Inhaled sodium cromoglycate for asthma in children.吸入性色甘酸钠治疗儿童哮喘
Cochrane Database Syst Rev. 2008 Oct 8;2008(4):CD002173. doi: 10.1002/14651858.CD002173.pub2.
2
Cromoglycate and nedocromil: influence on airway reactivity.色甘酸和奈多罗米:对气道反应性的影响。
Mediators Inflamm. 1994;3(7):S15-9. doi: 10.1155/S0962935194000694.
3
The pharmacology of airway hyperresponsiveness and inflammation.气道高反应性与炎症的药理学
Lung. 1990;168 Suppl:221-9. doi: 10.1007/BF02718136.