Stroh Inna G, Moradi Ahmadreza, Burkholder Bryn M, Hornbeak Dana M, Leung Theresa G, Thorne Jennifer E
a Division of Ocular Immunology, Department of Ophthalmology , The Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore , Maryland , USA.
b Department of Epidemiology , The Johns Hopkins University Bloomberg School of Public Health , Baltimore , Maryland , USA.
Ocul Immunol Inflamm. 2017 Aug;25(4):503-512. doi: 10.3109/09273948.2016.1142573. Epub 2016 Mar 22.
To describe the incidence of ocular hypertension (OHT) and secondary glaucoma (SG) in JIA-associated uveitis, identify risk factors for development of these complications, and describe their effect on visual outcomes.
A retrospective cohort of 108 patients (196 eyes) with JIA-associated uveitis seen over 30 years at an academic practice.
Of examined eyes, 40% had OHT or SG at presentation. These eyes had a nearly three-fold higher incidence of legal blindness during follow-up, compared with eyes without OHT or SG. An additional 41 eyes developed OHT or SG during follow-up. Presenting with anterior uveitis, active inflammation, and using systemic corticosteroids were risk factors for developing OHT, while use of immunosuppressive medication at presentation reduced this risk. Risk factors for developing SG included anterior uveitis and use of systemic corticosteroids.
OHT and SG were common in patients with JIA-associated uveitis. Use of immunosuppressive drugs may decrease the risk of developing OHT.
描述幼年特发性关节炎（JIA）相关葡萄膜炎患者中高眼压（OHT）和继发性青光眼（SG）的发生率，确定这些并发症发生的危险因素，并描述它们对视力预后的影响。
对在一所学术机构30年间诊治的108例（196只眼）JIA相关葡萄膜炎患者进行回顾性队列研究。
在检查的眼中，40%在初诊时患有OHT或SG。与未患OHT或SG的眼睛相比，这些眼睛在随访期间法定失明的发生率高出近三倍。另外41只眼在随访期间发生了OHT或SG。初诊时表现为前葡萄膜炎、存在活动性炎症以及使用全身糖皮质激素是发生OHT的危险因素，而初诊时使用免疫抑制药物可降低这种风险。发生SG的危险因素包括前葡萄膜炎和使用全身糖皮质激素。
OHT和SG在JIA相关葡萄膜炎患者中很常见。使用免疫抑制药物可能会降低发生OHT的风险。
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