Brix Lau, Ringgaard Steffen, Sandager Puk, Petersen Olav Bjørn, Sørensen Thomas Sangild, Lundorf Erik, Stausbøl-Grøn Brian
Department of Procurement & Clinical Engineering, Region Midt, Aarhus N, Denmark.
MR Research Centre, Aarhus University Hospital, Aarhus N, Denmark.
Clin Physiol Funct Imaging. 2017 Nov;37(6):717-722. doi: 10.1111/cpf.12364. Epub 2016 Mar 22.
Foetal MRI has become an established image modality in the prenatal diagnosis of CNS anomalies, but image quality can be severely affected by foetal movements. The objective was to overcome these inherent motion problems by applying interactive real-time MRI and to evaluate the diagnostic usefulness of the applied real-time MRI sequence in relation to standard protocols.
Ten healthy foetuses (gestation week 21·3 ± 0·5) were scanned using a system, which allowed visual feedback and interactive slice positioning in real time. The data were compared to a control group of 14 healthy foetuses (gestation week 21·0 ± 0·8) who had previously been scanned using standard MRI. Comparisons were carried out by two radiologists with regard to cerebral anthropometric sizes, presence of important brain structures, degree of movement, clinical image value, image quality and ability to obtain correct slice planes.
Two out of eight anthropometric sizes were statistically different between the two groups. Representation of cerebral structures was found in 70-100% in the real-time group. No statistically differences were found in clinical image value and image quality. The mean ability to obtain optimal slice planes was higher in the real-time group, but it was not significant.
Imaging of the foetal brain using the proposed interactive real-time MRI system is a promising alternative to traditional foetal MRI for anthropometrics or as a supplement for the representation of foetal brain structures in cases in which foetal motion causes challenges in relation to obtaining optimal slice planes using conventional MRI techniques.
胎儿磁共振成像（MRI）已成为中枢神经系统异常产前诊断中一种既定的成像方式，但图像质量会受到胎儿运动的严重影响。目的是通过应用交互式实时MRI来克服这些固有的运动问题，并评估所应用的实时MRI序列相对于标准协议的诊断效用。
使用一个允许实时视觉反馈和交互式切片定位的系统对10名健康胎儿（妊娠周数21.3±0.5）进行扫描。将数据与14名健康胎儿的对照组（妊娠周数21.0±0.8）进行比较，这些对照组胎儿之前已使用标准MRI进行扫描。两名放射科医生就脑人体测量尺寸、重要脑结构的存在、运动程度、临床图像价值、图像质量以及获得正确切片平面的能力进行了比较。
两组之间八个人体测量尺寸中的两个在统计学上存在差异。实时组中脑结构的显示率为70%-100%。临床图像价值和图像质量方面未发现统计学差异。实时组获得最佳切片平面的平均能力更高，但不显著。
使用所提出的交互式实时MRI系统对胎儿大脑进行成像，对于人体测量学而言，是传统胎儿MRI的一种有前景的替代方法，或者在胎儿运动给使用传统MRI技术获得最佳切片平面带来挑战的情况下，作为显示胎儿脑结构的补充方法。
